| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3635111 | F | Invivo inhibition of Lp-PLA2 in Sprague-Dawley rat at 25 mg/kg, po measured over 24 hrs | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 2. | ALA3635112 | F | Invivo inhibition of Lp-PLA2 in Sprague-Dawley rat at 25 mg/kg, po after 5 hrs | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 3. | ALA3635113 | A | Metabolic stability in Wistar rat liver S9 fractions assessed as half life at 0.1 uM in presence of NADPH | Rattus norvegicus | 7 | subcellular format | Scientific Literature | ||
| 4. | ALA3635114 | A | Metabolic stability in human liver S9 fractions assessed as half life at 0.1 uM in presence of NADPH | Homo sapiens | 7 | subcellular format | Scientific Literature | ||
| 5. | ALA3635116 | B | Invivo inhibition of Lp-PLA2 in mouse plasma at 100 nM after 24 hrs | Mus musculus | 4 | single protein format | Scientific Literature | ||
| 6. | ALA3635117 | B | Inhibition of Lp-PLA2 in mouse plasma at 1 uM using 2-thio-PAF substrate after 10 mins | Mus musculus | 8 | single protein format | Scientific Literature | ||
| 7. | ALA3635118 | B | Inhibition of Lp-PLA2 in Sprague-Dawley rat plasma at 10 nM using 2-thio-PAF substrate after 10 mins | Rattus norvegicus | 5 | cell-free format | Scientific Literature | ||
| 8. | ALA3635119 | B | Inhibition of Lp-PLA2 in Sprague-Dawley rat plasma at 100 nM using 2-thio-PAF substrate after 10 mins | Rattus norvegicus | 8 | cell-free format | Scientific Literature | ||
| 9. | ALA3635120 | B | Inhibition of Lp-PLA2 in human plasma at 10 nM using 2-thio-PAF substrate after 10 mins | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 10. | ALA3635121 | B | Inhibition of Lp-PLA2 in human plasma at 100 nM using 2-thio-PAF substrate after 10 mins | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 11. | ALA3635122 | B | Inhibition of recombinant human Lp-PLA2 using 2-thio-PAF substrate after 10 mins | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 12. | ALA3635123 | B | Inhibition of recombinant human Lp-PLA2 at 100 nM using 2-thio-PAF substrate after 10 mins | Homo sapiens | 27 | single protein format | Scientific Literature | ||
| 13. | ALA3635126 | A | Cmax in Sprague-Dawley rat at 25 mg/kg, po after 48 hrs by LC-MS method | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 14. | ALA3635127 | B | Inhibition of recombinant human Lp-PLA2 at 10 nM using 2-thio-PAF substrate after 10 mins | Homo sapiens | 19 | single protein format | Scientific Literature | ||
| 15. | ALA3635129 | A | AUC (0 to infinity) in Sprague-Dawley rat at 25 mg/kg, po after 48 hrs by LC-MS method | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 16. | ALA3635255 | A | Terminal half life in Sprague-Dawley rat at 25 mg/kg, po after 48 hrs by LC-MS method | Rattus norvegicus | 4 | organism-based format | Scientific Literature |
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