# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3705713 | B | Inhibition Assay: The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay (Greenlee et al., J Pharmacol Exp Ther, 1978). Our first studies were with highly purified human CYP2A6 that provided a convenient and relatively high-throughput measure of CYP2A6 inhibition. | Homo sapiens | 89 | single protein format | BindingDB Database | ||
2. | ALA4422401 | B | Inhibition of human CYP2A6 expressed in insect cell microsomes assessed as reduction in enzyme-mediated coumarin 7-hydroxylation | Homo sapiens | 111 | assay format | Patent Bioactivity Data | ||
3. | ALA4422402 | B | Selectivity index, ratio of IC50 for inhibition of human CYP3A4 assessed as reduction in enzyme-mediated testosterone 6-hydroxylation to IC50 for inhibition of human CYP2A6 assessed as reduction in enzyme-mediated coumarin 7-hydroxylation | Homo sapiens | 106 | assay format | Patent Bioactivity Data | ||
4. | ALA4422403 | A | Inhibition of CYP3A4 in human liver microsomes assessed as reduction in enzyme-mediated testosterone 6-hydroxylation in presence of NADPH-generating system, G6P and G6P dehydrogenase | Homo sapiens | 106 | microsome format | Patent Bioactivity Data | ||
5. | ALA4422428 | A | Inhibition of CYP2A13 (unknown origin) at 1 uM relative to control | Homo sapiens | 35 | single protein format | Patent Bioactivity Data | ||
6. | ALA4422429 | A | Inhibition of mouse CYP2A5 (unknown origin) | Mus musculus | 35 | single protein format | Patent Bioactivity Data |