# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA702836 | F | Transthyretin (TTR) amyloidogenesis inhibition activity by employing an acid-mediated (pH 4.4) WTTTR amyloid fibril formation assay, at 3.6 uM conc. | 27 | assay format | Scientific Literature | |||
2. | ALA702837 | F | Transthyretin (TTR) amyloidogenesis inhibition activity by employing an acid-mediated (pH 4.4) WTTTR amyloid fibril formation assay, at 7.2 uM conc. | 55 | assay format | Scientific Literature | |||
3. | ALA813228 | B | Ability to bind TTR selectively over all other proteins in human blood plasma (equiv bound) | 24 | cell-free format | Scientific Literature | |||
4. | ALA3252206 | F | Antiinflammatory activity against carrageenan-induced foot edema in rat administered via gastric gavage | Rattus norvegicus | 29 | organism-based format | Scientific Literature | ||
5. | ALA4055896 | B | Inhibition of acid-induced wild type transthyretin (unknown origin) aggregation expressed in Escherichia coli pre-incubated for 30 mins before acid addition and further incubated for 72 hrs at 37 degC under dark conditions by UV-Vis spectrophotometry | Homo sapiens | 289 | assay format | Scientific Literature | ||
6. | ALA4055897 | B | Binding affinity to transthyretin in human blood plasma assessed as plasma binding selectivity by measuring stoichiometry of small molecule bound to TTR incubated for 24 hrs at 37 degC by RP-HPLC | Homo sapiens | 288 | single protein format | Scientific Literature | ||
7. | ALA4775521 | B | Inhibition of human ACMSD assessed as QUIN level at 1 mM by HPLC analysis (Rvb = 16.4 +/- 2.9%) | Homo sapiens | 26 | single protein format | Scientific Literature | ||
8. | ALA4775522 | B | Inhibition of human ACMSD assessed as picolinic acid level at 1 mM by HPLC analysis (Rvb = 83.6 +/- 3.1%) | Homo sapiens | 26 | single protein format | Scientific Literature | ||
9. | ALA4775525 | B | Inhibition of human ACMSD using ACMS substrate by spectrometry | Homo sapiens | 16 | single protein format | Scientific Literature |