# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3720978 | F | Neuroprotection in CD1 mouse primary cortical neuron assessed as reduction in stretch injury-induced cell death at 2 to 10 uM dosed 1 hr after injury by propidium iodide straining based | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
2. | ALA3720979 | F | Neuroprotection in Sprague-Dawley rat model of fluid percussion injury assessed as reduction in neuronal brain damage dosed before injury at 2 to 10 uM by TTC staining based oscilloscopy | Rattus norvegicus | 1 | organism-based format | Patent Bioactivity Data | ||
3. | ALA3720980 | B | Inhibition of N-terminal Flag-tagged mouse TRPM7 expressed in HEK293T cells assessed as reduction in whole cell currents by whole-cell patch clamp assay | Mus musculus | 14 | cell-based format | Patent Bioactivity Data | ||
4. | ALA3720981 | F | Neuroprotection in Sprague-Dawley rat model of fluid percussion injury assessed as increase in balance by measuring mean latency measured on first day post injury by rotarod performance test relative to untreated control | Rattus norvegicus | 1 | organism-based format | Patent Bioactivity Data | ||
5. | ALA3720982 | F | Neuroprotection in Sprague-Dawley rat model of fluid percussion injury assessed as improvement in learning and memory tasks by measuring latency to reach platform dosed 1 hr after lateral fluid percussion injury by Morris water maze test | Rattus norvegicus | 1 | organism-based format | Patent Bioactivity Data | ||
6. | ALA3720983 | B | Inhibition of N-terminal Flag-tagged mouse TRPM7 expressed in HEK293T cells assessed as reduction in whole cell currents under oxygen-glucose deprivation by whole-cell patch clamp assay | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
7. | ALA3721037 | F | Neuroprotection in Sprague-Dawley rat model of fluid percussion injury assessed as reduction in neuronal damage dosed 1 hr after injury by TTC staining based oscilloscopy | Rattus norvegicus | 1 | organism-based format | Patent Bioactivity Data | ||
8. | ALA3721038 | F | Neuroprotection in Sprague-Dawley rat model of fluid percussion injury assessed as distance traveled by rotarod performance test relative to untreated control | Rattus norvegicus | 1 | organism-based format | Patent Bioactivity Data | ||
9. | ALA3721039 | F | Neuroprotection in Sprague-Dawley rat model of fluid percussion injury assessed as activity parameters by rotarod performance test relative to untreated control | Rattus norvegicus | 1 | organism-based format | Patent Bioactivity Data | ||
10. | ALA3721046 | F | Antiproliferative activity against human WERI cells assessed as inhibition of cell proliferation by propidium iodide uptake based fluoroskan microplate reader analysis | Homo sapiens | 101 | cell-based format | Patent Bioactivity Data | ||
11. | ALA3734564 | B | Inhibition of TRPM7 in Sprague-Dawley rat retinal explants subjected to 1 hr oxygen-glucose deprivation assessed as reduction in retinal ischemia at 5 uM | Rattus norvegicus | 3 | single protein format | Patent Bioactivity Data | ||
12. | ALA3734565 | B | Inhibition of sodium channel in mouse cortical neurons assessed as effect on Na+ currents | Mus musculus | 3 | assay format | Patent Bioactivity Data | ||
13. | ALA3734566 | F | Inhibition of TRPA1 ((unknown origin) expressed in HEK293 cells assessed as effect on agonist-induced Ca2+ changes | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
14. | ALA3734567 | B | Inhibition of Tet-induced Flag-tagged mouse TRPM7 expressed in HEK293 cells assessed as inhibition of channel-mediated cell death in presence of Mg2+ incubated for 24 to 48 hrs by propidium iodide uptake assay | Mus musculus | 359 | cell-based format | Patent Bioactivity Data | ||
15. | ALA3734569 | B | Inhibition of Tet-induced Flag-tagged mouse TRPM7 expressed in HEK293 cells assessed as reduction in channel currents at 0.3 to 30 uM by whole cell patch clamp assay | Mus musculus | 6 | cell-based format | Patent Bioactivity Data | ||
16. | ALA3734570 | B | Inhibition of TRPM7 in rat H9C2 cells assessed as reduction in channel currents at 0.3 to 30 uM by whole cell patch clamp assay | Rattus norvegicus | 6 | cell-based format | Patent Bioactivity Data | ||
17. | ALA3734571 | F | Inhibition of calcium channel in mouse cortical neurons assessed as effect on Ca2+ currents | Mus musculus | 3 | assay format | Patent Bioactivity Data | ||
18. | ALA3734572 | B | Inhibition of potassium channel in mouse cortical neurons assessed as reduction in potassium currents at -10mV membrane potential | Mus musculus | 1 | assay format | Patent Bioactivity Data | ||
19. | ALA3734573 | F | Inhibition of TRPM2 (unknown origin) expressed in HEK293 cells assessed as effect on agonist-induced Ca2+ changes | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
20. | ALA3734574 | F | Inhibition of TRPM4 (unknown origin) expressed in HEK293 cells assessed as effect on agonist-induced Ca2+ changes | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data |