# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3734172 | F | Antagonist activity against PAR4 in human platelet rich plasma assessed as inhibition of tissue factor-induced platelet aggregation pre-incubated for 2 mins before Cacl2 and tissue factor addition by optical or impedance aggregometry | Homo sapiens | 1 | ALA3727363 | cell-free format | Patent Bioactivity Data | |
2. | ALA3734174 | F | Antagonist activity against human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2-induced intracellular calcium mobilization incubated for 30 mins before agonist addition by FLIPR assay | Homo sapiens | 402 | ALA3727363 | cell-based format | Patent Bioactivity Data | |
3. | ALA4407126 | B | Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins followed by gamma-thrombin addition and measured every 50 secs for up to 15 mins starting from 10 secs post gamma-thrombin addition in presence of recombinant hirudin | Homo sapiens | 22 | ALA4406800 | assay format | Scientific Literature | |
4. | ALA4407127 | F | Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization preincubated for 30 mins followed by AYPGKF addition and measured by calcium indicator-based FLIPR assay | Homo sapiens | 44 | ALA4406800 | cell-based format | Scientific Literature | |
5. | ALA4407129 | A | Stability in human liver microsomes assessed as parent compound remaining measured after 10 mins | Homo sapiens | 44 | ALA4406800 | microsome format | Scientific Literature | |
6. | ALA4407130 | A | Stability in rat liver microsomes assessed as parent compound remaining measured after 10 mins | Rattus norvegicus | 44 | ALA4406800 | microsome format | Scientific Literature | |
7. | ALA4407131 | A | Half life in human liver microsomes | Homo sapiens | 5 | ALA4406800 | microsome format | Scientific Literature | |
8. | ALA4407132 | B | Antagonist activity at PAR4 in human platelet rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins followed by gamma-thrombin addition and measured in presence of recombinant hirudin | Homo sapiens | 34 | ALA4406800 | cell-free format | Scientific Literature | |
9. | ALA4407133 | A | Half life in rat liver microsomes | Rattus norvegicus | 3 | ALA4406800 | microsome format | Scientific Literature | |
10. | ALA4407134 | A | Clearance in rat at 2 mg/kg, po or 0.5 mg/kg, iv administered as infusion for 10 mins | Rattus norvegicus | 3 | ALA4406800 | organism-based format | Scientific Literature | |
11. | ALA4407135 | A | Half life in rat at 2 mg/kg, po or 0.5 mg/kg, iv administered as infusion for 10 mins | Rattus norvegicus | 3 | ALA4406800 | organism-based format | Scientific Literature | |
12. | ALA4407136 | A | Oral bioavailability in rat at 2 mg/kg | Rattus norvegicus | 3 | ALA4406800 | organism-based format | Scientific Literature |