# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3734311 | B | Binding affinity to Gbetagamma in human HL60 cells assessed as inhibition of fMLP-stimulated GFP-PHAkt translocation to plasma membrane at 10 uM incubated for 5 mins prior to fMLP stimulation by Western blot analysis | Homo sapiens | 3 | cell-based format | Patent Bioactivity Data | ||
2. | ALA3734313 | B | Binding affinity to biotinylated Gbeta1gamma2 (unknown origin) by SPR analysis | Homo sapiens | 1 | protein complex format | Patent Bioactivity Data | ||
3. | ALA3734315 | B | Binding affinity to Gbetagamma in differentiated human HL60 cells assessed as inhibition of fMLP-stimulated Rac1 activation at 10 uM preincubated for 10 mins followed by fMLP challenge for 90 secs by Western blot analysis | Homo sapiens | 3 | cell-based format | Patent Bioactivity Data | ||
4. | ALA3734316 | F | Antiinflammatory activity in ip dosed Swiss-Webster mouse assessed as inhibition of carrageenan-induced paw edema administered 1 hr followed by carrageenan challenge measured 3 times every 2 hrs | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
5. | ALA3734317 | B | Binding affinity to Gbetagamma in differentiated human HL60 cells assessed as inhibition of fMLP-stimulated superoxide production at 10 uM preincubated for 10 mins followed by nitro blue tetrazolium addition for 5 mins and fMLP addition for 30 mins by NADPH oxidase assay | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
6. | ALA3734318 | A | Effect on paw thickness in Swiss-Webster mouse at 100 mg/kg, ip administered 1 hr | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
7. | ALA3734320 | F | Antiinflammatory activity in Swiss-Webster mouse carrageenan-induced paw edema model assessed as inhibition of neutrophils recruitment in edematous fluid at 100 mg/kg, ip administered 1 hr followed by carrageenan challenge | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
8. | ALA3734323 | F | Antiinflammatory activity in Swiss-Webster mouse carrageenan-induced paw edema model assessed as reduction of paw exudate volume at 100 mg/kg, ip administered 1 hr followed by carrageenan challenge | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
9. | ALA3734324 | F | Antiinflammatory activity in differentiated human HL60 cells assessed as inhibition of fMLP-stimulated cell migration at 10 uM after 1 hr by Boyden chamber method | Homo sapiens | 3 | cell-based format | Patent Bioactivity Data | ||
10. | ALA3734326 | F | Antiinflammatory activity in primary human neutrophils assessed as inhibition of GM-CSF-stimulated chemotaxis at 1 uM after 1 hr by Boyden chamber method | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
11. | ALA3734327 | F | Antiinflammatory activity in differentiated human HL60 cells assessed as inhibition of fMLP-stimulated chemotaxis by transwell assay | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
12. | ALA3734328 | F | Antiinflammatory activity in primary human neutrophils assessed as inhibition of fMLP-stimulated chemotaxis after 1 hr by Boyden chamber method | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
13. | ALA3734329 | F | Antiinflammatory activity in primary human neutrophils assessed as inhibition of IL8-stimulated chemotaxis after 1 hr by Boyden chamber method | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
14. | ALA3734332 | F | Antiinflammatory activity in Swiss-Webster mouse assessed as inhibition of carrageenan-induced paw edema at 30 mg/kg, po administered 1 hr followed by carrageenan challenge measured at 3 hrs | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
15. | ALA3734361 | B | Inhibition of Gbetagamma-GRK2 interaction in mouse cardiomyocytes assessed as increase in contractility | Mus musculus | 3 | cell-based format | Patent Bioactivity Data | ||
16. | ALA3734362 | B | Inhibition of Gbetagamma-GRK2 interaction in mouse cardiomyocytes assessed as increase in isoproterenol-induced contractility | Mus musculus | 3 | cell-based format | Patent Bioactivity Data | ||
17. | ALA3734371 | T | Toxicity in C57/B16 mouse liver at 10 to 100 mg/kg/day administered for 2 weeks by histological analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
18. | ALA3734372 | T | Toxicity in C57/B16 mouse lung at 10 to 100 mg/kg/day administered for 2 weeks by histological analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
19. | ALA3734373 | T | Toxicity in C57/B16 mouse brain at 10 to 100 mg/kg/day administered for 2 weeks by histological analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
20. | ALA3734374 | T | Toxicity in C57/B16 mouse heart at 10 to 100 mg/kg/day administered for 2 weeks by histological analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data |