# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3737980 | B | Selectivity index, ratio of IC50 for Abl T315I mutant (unknown origin) to IC50 for human wild-type Abl | Homo sapiens | 17 | ALA3734755 | assay format | Scientific Literature | |
2. | ALA3737981 | F | Growth inhibition of mouse BA/F3 cells expressing wild-type Bcr-Abl after 48 hrs by MTT assay | Mus musculus | 17 | ALA3734755 | cell-based format | Scientific Literature | |
3. | ALA3737982 | A | Terminal half life in Sprague-Dawley rat at 2 mg/kg, iv by LC-MS analysis | Rattus norvegicus | 1 | ALA3734755 | organism-based format | Scientific Literature | |
4. | ALA3737983 | A | Cmax in Sprague-Dawley rat at 2 mg/kg, iv by LC-MS analysis | Rattus norvegicus | 1 | ALA3734755 | organism-based format | Scientific Literature | |
5. | ALA3737984 | A | Tmax in Sprague-Dawley rat at 2 mg/kg, iv by LC-MS analysis | Rattus norvegicus | 1 | ALA3734755 | organism-based format | Scientific Literature | |
6. | ALA3737985 | A | Effect on total STAT5 protein level in mouse BA/F3 cells at 500 nM after 3 hrs by western blot analysis | Mus musculus | 4 | ALA3734755 | cell-based format | Scientific Literature | |
7. | ALA3737986 | B | Inhibition of CSF1R (unknown origin) at 50 nM | Homo sapiens | 1 | ALA3734755 | single protein format | Scientific Literature | |
8. | ALA3737987 | B | Inhibition of Yes1 (unknown origin) at 50 nM | Homo sapiens | 1 | ALA3734755 | single protein format | Scientific Literature | |
9. | ALA3737988 | B | Inhibition of Blk (unknown origin) at 50 nM | Homo sapiens | 2 | ALA3734755 | single protein format | Scientific Literature | |
10. | ALA3737989 | B | Inhibition of MUSK (unknown origin) at 50 nM | Homo sapiens | 2 | ALA3734755 | single protein format | Scientific Literature | |
11. | ALA3737990 | B | Inhibition of TrkA (unknown origin) at 50 nM | Homo sapiens | 2 | ALA3734755 | single protein format | Scientific Literature | |
12. | ALA3737991 | A | AUC (0 to infinity) in Sprague-Dawley rat at 2 mg/kg, iv by LC-MS analysis | Rattus norvegicus | 1 | ALA3734755 | organism-based format | Scientific Literature | |
13. | ALA3737992 | B | Inhibition of human wild-type Abl after 30 mins by phosphocellulose paper disk assay using 0.1 mM EAIYAAPFAKKK peptide substrate | Homo sapiens | 17 | ALA3734755 | single protein format | Scientific Literature | |
14. | ALA3737993 | B | Inhibition of Abl T315I mutant (unknown origin) after 30 mins by phosphocellulose paper disk assay using 0.1 mM EAIYAAPFAKKK peptide substrate | Homo sapiens | 17 | ALA3734755 | single protein format | Scientific Literature | |
15. | ALA3737994 | F | Growth inhibition of mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 48 hrs by MTT assay | Mus musculus | 17 | ALA3734755 | cell-based format | Scientific Literature | |
16. | ALA3737995 | F | Selectivity index, Ratio of IC50 for mouse BA/F3 cells expressing Bcr-Abl T315I mutant to IC50 for mouse BA/F3 cells expressing wild-type Bcr-Abl | Mus musculus | 17 | ALA3734755 | cell-based format | Scientific Literature | |
17. | ALA3737996 | F | Growth inhibition of mouse BA/F3 cells at <1 uM after 48 hrs by MTT assay | Mus musculus | 2 | ALA3734755 | cell-based format | Scientific Literature | |
18. | ALA3737997 | B | Inhibition of Bcr-Abl (unknown origin) expressed in mouse BA/F3 cells assessed as suppression of Abl phosphorylation at Y412 at 500 nM for 3 hrs by western blot analysis | Homo sapiens | 5 | ALA3734755 | cell-based format | Scientific Literature | |
19. | ALA3737998 | B | Inhibition of Bcr-Abl T315I mutant (unknown origin) expressed in mouse BA/F3 cells assessed as suppression of Abl phosphorylation at Y412 at 500 nM for 3 hrs by western blot analysis | Homo sapiens | 5 | ALA3734755 | cell-based format | Scientific Literature | |
20. | ALA3737999 | B | Inhibition of Bcr-Abl (unknown origin) expressed in mouse BA/F3 cells assessed as suppression of STAT5 phosphorylation at Y694 at 500 nM for 3 hrs by western blot analysis | Homo sapiens | 5 | ALA3734755 | cell-based format | Scientific Literature |