# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3736726 | ADME | Metabolic stability in rat liver microsomes after 5 to 180 mins by HPLC-UV analysis | Rattus norvegicus | 4 | ALA3734674 | tissue-based format | Scientific Literature | |
2. | ALA3736727 | ADME | Half life in rat liver microsomes at 100 uM after 5 to 180 mins by HPLC-UV analysis | Rattus norvegicus | 4 | ALA3734674 | tissue-based format | Scientific Literature | |
3. | ALA3736728 | Toxicity | Acute toxicity in KM mouse assessed as mortality at 677 to 2000 mg/kg, po measured for 4 hrs | Mus musculus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
4. | ALA3736729 | Toxicity | Acute toxicity in KM mouse assessed as abnormal changes in water consumption at 677 to 2000 mg/kg, po measured for 4 hrs | Mus musculus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
5. | ALA3736730 | Toxicity | Acute toxicity in KM mouse assessed as abnormal changes in food consumption at 677 to 2000 mg/kg, po measured for 4 hrs | Mus musculus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
6. | ALA3736731 | Toxicity | Acute toxicity in KM mouse assessed as change in body weight at 677 to 2000 mg/kg, po measured for 14 days | Mus musculus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
7. | ALA3736732 | Toxicity | Acute toxicity in KM mouse assessed as damage to heart at 677 to 2000 mg/kg, po measured on day 14 | Mus musculus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
8. | ALA3736733 | Toxicity | Acute toxicity in KM mouse assessed as damage to liver at 677 to 2000 mg/kg, po measured on day 14 | Mus musculus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
9. | ALA3736734 | Toxicity | Acute toxicity in KM mouse assessed as damage to kidney at 677 to 2000 mg/kg, po measured on day 14 | Mus musculus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
10. | ALA3736735 | Toxicity | Toxicity in Wistar rat amyloid beta-induced Alzheimer's disease model assessed as change in body weight at 30 mg/kg/day administered as intragastric infusion for 32 days measured during compound dosing by Morris water maze assay | Rattus norvegicus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
11. | ALA3736736 | Toxicity | Toxicity in Wistar rat amyloid beta-induced Alzheimer's disease model assessed as emesis-like behavior at 30 mg/kg/day administered as intragastric infusion for 32 days measured during compound dosing by Morris water maze assay | Rattus norvegicus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
12. | ALA3736737 | Toxicity | Toxicity in Wistar rat amyloid beta-induced Alzheimer's disease model assessed as diarrhea-like behavior at 30 mg/kg/day administered as intragastric infusion for 32 days measured during compound dosing by Morris water maze assay | Rattus norvegicus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
13. | ALA3736738 | Toxicity | Toxicity in Wistar rat amyloid beta-induced Alzheimer's disease model assessed as effect on survival at 30 mg/kg/day administered as intragastric infusion for 32 days measured during compound dosing by Morris water maze assay | Rattus norvegicus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
14. | ALA3736739 | Functional | Cognitive enhancing effect in Wistar rat amyloid beta-induced Alzheimer's disease model assessed as reduction in escape latency at 30 mg/kg/day administered as intragastric infusion for 32 days measured during compound dosing by Morris water maze assay | Rattus norvegicus | 2 | ALA3734674 | organism-based format | Scientific Literature | |
15. | ALA3736740 | Functional | Cognitive enhancing effect in Wistar rat amyloid beta-induced Alzheimer's disease model assessed as virtual platform crossing at 30 mg/kg/day administered as intragastric infusion for 32 days measured 24 hrs post last dose by Morris water maze assay (Rvb = 2.1 +/- 0.9 No_unit ) | Rattus norvegicus | 2 | ALA3734674 | organism-based format | Scientific Literature | |
16. | ALA3736742 | Functional | Cognitive enhancing effect in Wistar rat amyloid beta-induced Alzheimer's disease model assessed as swimming speed at 30 mg/kg/day administered as intragastric infusion for 32 days measured 24 hrs post last dose by Morris water maze assay (Rvb = 21 +/- 3.1 cm/s ) | Rattus norvegicus | 2 | ALA3734674 | organism-based format | Scientific Literature | |
17. | ALA3736744 | Functional | Cognitive enhancing effect in Wistar rat amyloid beta-induced Alzheimer's disease model assessed as swimming path length in virtual platform at 30 mg/kg/day administered as intragastric infusion for 32 days measured 24 hrs post last dose by Morris water maze assay (Rvb = 10.8 +/- 5.4 cm ) | Rattus norvegicus | 2 | ALA3734674 | organism-based format | Scientific Literature | |
18. | ALA3736876 | Functional | Cognitive enhancing effect in Wistar rat amyloid beta-induced Alzheimer's disease model assessed as time spent in virtual platform at 30 mg/kg/day administered as intragastric infusion for 32 days measured 24 hrs post last dose by Morris water maze assay (Rvb = 0.9 +/- 0.6 secs ) | Rattus norvegicus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
19. | ALA3736877 | Functional | Cognitive enhancing effect in Wistar rat amyloid beta-induced Alzheimer's disease model assessed as swimming path length in effective region at 30 mg/kg/day administered as intragastric infusion for 32 days measured 24 hrs post last dose by Morris water maze assay (Rvb = 72.1 +/- 6 cm ) | Rattus norvegicus | 1 | ALA3734674 | organism-based format | Scientific Literature | |
20. | ALA3736879 | Functional | Cognitive enhancing effect in Wistar rat amyloid beta-induced Alzheimer's disease model assessed as time spent in effective region at 30 mg/kg/day administered as intragastric infusion for 32 days measured 24 hrs post last dose by Morris water maze assay (Rvb = 3.3 +/- 1.1 secs ) | Rattus norvegicus | 2 | ALA3734674 | organism-based format | Scientific Literature |