Antitumor activity against NPM-ALK-positive human KARPAS299 cells xenografted in SCID mouse assessed as decrease in tumor volume at 20 mg/kg, po qd administered for 11 days measured on day 11 post last dose
Toxicity in NPM-ALK-positive human KARPAS299 cells xenografted SCID mouse assessed as increase in body weight at 20 mg/kg, po qd administered for 11 days measured twice a week
Antitumor activity against mouse NIH/3T3 cells expressing wild type EML4-ALK xenografted in nude mouse assessed as tumor growth inhibition at 40 mg/kg, po qd administered for 10 days
Antitumor activity against mouse NIH/3T3 cells expressing wild type EML4-ALK xenografted in nude mouse assessed as tumor growth inhibition at 20 mg/kg, po qd administered for 10 days
Antitumor activity against mouse NIH/3T3 cells expressing EML4-ALK L1196M mutant xenografted in nude mouse assessed as tumor growth inhibition at 40 mg/kg, po qd administered for 10 days
Antitumor activity against mouse NIH/3T3 cells expressing EML4-ALK L1196M mutant xenografted in nude mouse assessed as tumor growth inhibition at 20 mg/kg, po qd administered for 10 days