| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3743370 | B | Inhibition of rat NMDA receptor PCP binding site at 10 uM | Rattus norvegicus | 1 | ALA3739255 | protein complex format | Scientific Literature | |
| 2. | ALA3743371 | B | Inhibition of human PAC1 at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
| 3. | ALA3743372 | B | Inhibition of human ORL1 receptor at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
| 4. | ALA3743373 | B | Inhibition of human mu opioid receptor at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
| 5. | ALA3743374 | B | Inhibition of human TP prostanoid receptor at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
| 6. | ALA3743375 | B | Inhibition of human PPARgamma at 10 uM | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
| 7. | ALA3743376 | B | Inhibition of rat kappa opioid receptor at 10 uM by radioligand binding assay | Rattus norvegicus | 1 | ALA3739255 | single protein format | Scientific Literature | |
| 8. | ALA3743377 | B | Inhibition of human delta opioid receptor at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
| 9. | ALA3743378 | B | Inhibition of human neurotensin 1 receptor at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
| 10. | ALA3743379 | B | Inhibition of human neuropeptide Y2 receptor at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
| 11. | ALA3743380 | B | Inhibition of human neuropeptide Y1 receptor at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
| 12. | ALA3743381 | B | Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured every 1 sec for 60 secs followed by 3 sec intervals for 4 mins by FLIPR Ca2+ assay in presence of ionomycin | Homo sapiens | 21 | ALA3739255 | cell-based format | Scientific Literature | |
| 13. | ALA3743577 | A | Metabolic stability in human plasma at 10 uM after 4 hrs by LC/MS/MS analysis | Homo sapiens | 4 | ALA3739255 | cell-free format | Scientific Literature | |
| 14. | ALA3743578 | A | Metabolic stability in rat plasma at 10 uM after 4 hrs by LC/MS/MS analysis | Rattus norvegicus | 4 | ALA3739255 | cell-free format | Scientific Literature | |
| 15. | ALA3743579 | B | Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP addition for 30 mins by ELISA assay | Homo sapiens | 11 | ALA3739255 | tissue-based format | Scientific Literature | |
| 16. | ALA3743580 | B | Antagonist activity at rat P2X7R expressed in BzATP-stimulated HEK293 cells incubated for 20 mins followed by BzATP stimulation measured every 1 sec for 60 secs followed by 3 sec intervals for 4 mins by FLIPR Ca2+ assay in presence of ionomycin | Rattus norvegicus | 1 | ALA3739255 | cell-based format | Scientific Literature | |
| 17. | ALA3743582 | A | Drug metabolism in human liver microsomes assessed as GSH adduct UV peak area at 20 uM preincubated for 5 mins followed by NADPH addition measured after 60 mins by LC/MS/MS analysis relative to total area of GSH adduct, other metabolites, parent compound | Homo sapiens | 7 | ALA3739255 | tissue-based format | Scientific Literature | |
| 18. | ALA3743583 | A | Drug metabolism in rat liver microsomes assessed as GSH adduct UV peak area at 20 uM preincubated for 5 mins followed by NADPH addition measured after 60 mins by LC/MS/MS analysis relative to total area of GSH adduct, other metabolites, parent compound | Rattus norvegicus | 7 | ALA3739255 | tissue-based format | Scientific Literature | |
| 19. | ALA3743584 | A | Oral bioavailability in rat at 2 mg/kg administered as single dose | Rattus norvegicus | 3 | ALA3739255 | organism-based format | Scientific Literature | |
| 20. | ALA3743585 | A | Dose normalized AUC in rat at 2 mg/kg, po administered as single dose | Rattus norvegicus | 3 | ALA3739255 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!