| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3743816 | B | Inhibition of PARP in human HeLa cells assessed as induction of centrosome declustering after 48 hrs by DAPI-staining based image analysis | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 2. | ALA3743817 | P | Lipophilicity, log D of the compound at pH 7.4 | 11 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA3743818 | P | Solubility of the compound in water at pH 7.4 | 13 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA3743819 | A | Fraction unbound in human plasma | Homo sapiens | 6 | cell-free format | Scientific Literature | ||
| 5. | ALA3743820 | A | Intrinsic clearance in rat hepatocytes assessed per 10'6 cells | Rattus norvegicus | 14 | cell-based format | Scientific Literature | ||
| 6. | ALA3743821 | A | Clearance in iv dosed rat administered as bolus dose | Rattus norvegicus | 15 | organism-based format | Scientific Literature | ||
| 7. | ALA3743822 | A | Oral bioavailability in rat | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
| 8. | ALA3743823 | A | Apparent permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 9. | ALA3743824 | A | Efflux ratio of apparent permeability in human Caco2 cells | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 10. | ALA3743825 | B | Inhibition of full length human PARP1 expressed in Baculovirus infected Sf9 insect cells using activated DNA as substrate after 1 hr by streptavidin-horseradish peroxidase-based luminescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA3743826 | B | Inhibition of human PARP2 (2 to 583 residues) expressed in Baculovirus infected Sf9 insect cells using activated DNA as substrate after 1 hr by streptavidin-horseradish peroxidase-based luminescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA3743827 | B | Inhibition of PARP3 (unknown origin) using activated DNA as substrate after 1 hr by streptavidin-horseradish peroxidase-based luminescence assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 13. | ALA3743828 | B | Inhibition of human TNKS1 (1001 to 1327 residues) expressed in Baculovirus infected Sf9 insect cells using activated DNA as substrate after 1 hr by streptavidin-horseradish peroxidase-based luminescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA3743829 | B | Inhibition of human TNKS2 (667 to 1166 residues) expressed in Baculovirus infected Sf9 insect cells using activated DNA as substrate after 1 hr by streptavidin-horseradish peroxidase-based luminescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA3743830 | A | Intrinsic clearance in human hepatocytes assessed per 10'6 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA3743831 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 17. | ALA3743832 | A | Fraction unbound in rat plasma | Rattus norvegicus | 2 | cell-free format | Scientific Literature | ||
| 18. | ALA3743833 | A | Volume of distribution at steady state in rat | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA3743834 | A | Terminal half life in iv dosed rat | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA3743835 | A | Intrinsic clearance in mouse hepatocytes assessed per 10'6 cells | Mus musculus | 2 | cell-based format | Scientific Literature |
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