# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3744410 | Functional | Antiinflammatory activity in LPS-induced ICR mouse peritoneal macrophages assessed as suppression of TNF-alpha release pretreated for 2 hrs followed by stimulation with LPS for 22 hrs by ELISA | Mus musculus | 6 | ALA3739320 | cell-based format | Scientific Literature | |
2. | ALA3744411 | Functional | Antiinflammatory activity in LPS-induced mouse RAW264.7 macrophages assessed as suppression of TNF-alpha release pretreated at 10 uM for 2 hrs followed by stimulation with LPS for 22 hrs by ELISA | Mus musculus | 21 | ALA3739320 | cell-based format | Scientific Literature | |
3. | ALA3744412 | ADME | Cytotoxicity against human HL-7702 cells at 10 uM after 24 hrs by MTT assay | Homo sapiens | 33 | ALA3739320 | cell-based format | Scientific Literature | |
4. | ALA3744413 | Functional | Antiinflammatory activity in LPS-induced mouse RAW264.7 macrophages assessed as suppression of TNF-alpha release pretreated for 2 hrs followed by stimulation with LPS for 22 hrs by ELISA | Mus musculus | 6 | ALA3739320 | cell-based format | Scientific Literature | |
5. | ALA3744414 | Functional | Antiinflammatory activity in LPS-induced ICR mouse peritoneal macrophages assessed as suppression of IL-6 release pretreated for 2 hrs followed by stimulation with LPS for 22 hrs by ELISA | Mus musculus | 6 | ALA3739320 | cell-based format | Scientific Literature | |
6. | ALA3745107 | Functional | Antiinflammatory activity in LPS-induced mouse RAW264.7 macrophages assessed as suppression of IL-6 release pretreated for 2 hrs followed by stimulation with LPS for 22 hrs by ELISA | Mus musculus | 6 | ALA3739320 | cell-based format | Scientific Literature | |
7. | ALA3745284 | Functional | Antiinflammatory activity in LPS-induced mouse RAW264.7 macrophages assessed as suppression of TNF-alpha mRNA level pretreated at 10 uM for 2 hrs followed by stimulation with LPS for 6 hrs by RT-qPCR analysis | Mus musculus | 6 | ALA3739320 | cell-based format | Scientific Literature | |
8. | ALA3745285 | Functional | Antiinflammatory activity in LPS-induced mouse RAW264.7 macrophages assessed as suppression of IL-6 mRNA level pretreated at 10 uM for 2 hrs followed by stimulation with LPS for 6 hrs by RT-qPCR analysis | Mus musculus | 6 | ALA3739320 | cell-based format | Scientific Literature | |
9. | ALA3745286 | Functional | Antiinflammatory activity in LPS-induced mouse RAW264.7 macrophages assessed as suppression of IL-1beta mRNA level pretreated at 10 uM for 2 hrs followed by stimulation with LPS for 6 hrs by RT-qPCR analysis | Mus musculus | 6 | ALA3739320 | cell-based format | Scientific Literature | |
10. | ALA3745287 | Functional | Antiinflammatory activity in LPS-induced mouse RAW264.7 macrophages assessed as suppression of COX-2 mRNA level pretreated at 10 uM for 2 hrs followed by stimulation with LPS for 6 hrs by RT-qPCR analysis | Mus musculus | 6 | ALA3739320 | cell-based format | Scientific Literature | |
11. | ALA3745288 | Functional | Antiinflammatory activity in LPS-induced mouse RAW264.7 macrophages assessed as suppression of TNF-alpha mRNA level pretreated for 2 hrs followed by stimulation with LPS for 6 hrs by RT-qPCR analysis | Mus musculus | 1 | ALA3739320 | cell-based format | Scientific Literature | |
12. | ALA3745289 | Functional | Antiinflammatory activity in LPS-induced mouse RAW264.7 macrophages assessed as suppression of IL-6 mRNA level pretreated for 2 hrs followed by stimulation with LPS for 6 hrs by RT-qPCR analysis | Mus musculus | 1 | ALA3739320 | cell-based format | Scientific Literature | |
13. | ALA3745290 | Functional | Antiinflammatory activity in LPS-induced mouse RAW264.7 macrophages assessed as suppression of IL-1beta mRNA level pretreated for 2 hrs followed by stimulation with LPS for 6 hrs by RT-qPCR analysis | Mus musculus | 1 | ALA3739320 | cell-based format | Scientific Literature | |
14. | ALA3745291 | Functional | Antiinflammatory activity in LPS-induced mouse RAW264.7 macrophages assessed as suppression of COX-2 mRNA level pretreated for 2 hrs followed by stimulation with LPS for 6 hrs by RT-qPCR analysis | Mus musculus | 1 | ALA3739320 | cell-based format | Scientific Literature | |
15. | ALA3745292 | Physicochemical | Stability in phosphate buffer at pH 7.4 by UV-visible absorption analysis | 2 | ALA3739320 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA3745293 | Binding | Inhibition of LPS-induced IkappaB-alpha degradation in LPS-induced mouse RAW264.7 cells pretreated for 2 hrs followed by stimulation with LPS for 1 hr by Western blot analysis | Mus musculus | 1 | ALA3739320 | cell-based format | Scientific Literature | |
17. | ALA3745294 | Binding | Inhibition of NFkappaB in LPS-induced mouse RAW264.7 cells assessed as increase in P65 in cytosol pretreated for 2 hrs followed by stimulation with LPS for 1 hr by Western blot analysis | Mus musculus | 1 | ALA3739320 | cell-based format | Scientific Literature | |
18. | ALA3745295 | Binding | Inhibition of NFkappaB in LPS-induced mouse RAW264.7 cells assessed as decrease in P65 in nucleus pretreated for 2 hrs followed by stimulation with LPS for 1 hr by Western blot analysis | Mus musculus | 1 | ALA3739320 | cell-based format | Scientific Literature | |
19. | ALA3745296 | Binding | Inhibition of NFkappaB in LPS-induced mouse RAW264.7 cells assessed as suppression of binding of NF-kappabeta with DNA in nucleus pretreated for 2 hrs followed by stimulation with LPS for 1 hr by EMSA | Mus musculus | 1 | ALA3739320 | cell-based format | Scientific Literature | |
20. | ALA3745297 | Functional | Antiinflammatory activity in LPS-induced C57BL/6 mouse assessed as survival rate pretreated at 10 mg/kg, iv for 15 mins followed by LPS stimulation measured for 7 days | Mus musculus | 1 | ALA3739320 | organism-based format | Scientific Literature |