# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3743922 | B | Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl]dodecanamide substrate preincubated for 10 mins | Homo sapiens | 42 | ALA3739420 | cell-based format | Scientific Literature | |
2. | ALA3743923 | P | Chemical stability in AC assay buffer at 10 uM at pH 4.5 under shaking by UPLC method | 6 | ALA3739420 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA3743924 | P | Stability in 1 % DMSO containing phosphate-buffered solution assessed as half life at 10 uM at pH 7.4 under shaking by UPLC method | 14 | ALA3739420 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3743925 | F | Inhibition of acid ceramidase in C57BL/6 mouse cerebral cortex at 10 mg/kg, ip after 24 hrs by bicinchoninic acid based protein assay | Mus musculus | 1 | ALA3739420 | organism-based format | Scientific Literature | |
5. | ALA3743926 | F | Inhibition of acid ceramidase in C57BL/6 mouse lung at 10 mg/kg, ip after 24 hrs by bicinchoninic acid based protein assay | Mus musculus | 1 | ALA3739420 | organism-based format | Scientific Literature | |
6. | ALA3743927 | F | Inhibition of acid ceramidase in C57BL/6 mouse lung assessed as increase in ceramide level at 10 mg/kg, ip upto 6 hrs by LC-MS method | Mus musculus | 1 | ALA3739420 | organism-based format | Scientific Literature | |
7. | ALA3743928 | F | Inhibition of acid ceramidase in C57BL/6 mouse lung assessed as increase in dihydroceramide level at 10 mg/kg, ip upto 6 hrs by LC-MS method | Mus musculus | 1 | ALA3739420 | organism-based format | Scientific Literature | |
8. | ALA3743929 | F | Inhibition of acid ceramidase in C57BL/6 mouse lung assessed as decrease in sphingosine level at 10 mg/kg, ip after 3 hrs by LC-MS method | Mus musculus | 1 | ALA3739420 | organism-based format | Scientific Literature | |
9. | ALA3743930 | F | Inhibition of acid ceramidase in C57BL/6 mouse lung assessed as decrease in sphingosine-1-phosphate level at 10 mg/kg, ip after 3 hrs by LC-MS method | Mus musculus | 1 | ALA3739420 | organism-based format | Scientific Literature | |
10. | ALA3743931 | F | Inhibition of acid ceramidase in C57BL/6 mouse cerebral cortex assessed as changes in sphingolipid level at 10 mg/kg, ip by LC-MS method | Mus musculus | 1 | ALA3739420 | organism-based format | Scientific Literature |