| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3750668 | B | Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIA | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 2. | ALA3750669 | B | Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assay | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 3. | ALA3750670 | B | Selectivity ratio of IC50 for human recombinant CYP11B1 to IC50 for human recombinant CYP11B2 | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 4. | ALA3750671 | B | Inhibition of human CYP19 at 10 uM preincubated for 10 mins with NADPH followed by protein addition measured after 90 mins by fluorometric analysis | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 5. | ALA3750672 | A | Half life in rat liver microsomes after 30 mins by LC/MS/MS analysis | Rattus norvegicus | 7 | tissue-based format | Scientific Literature | ||
| 6. | ALA3750673 | A | Half life in human liver microsomes after 30 mins by LC/MS/MS analysis | Homo sapiens | 7 | tissue-based format | Scientific Literature | ||
| 7. | ALA3750674 | P | Equilibrium solubility of the compound in buffer at pH 6.8 | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA3750675 | A | Clearance in continuous angiotensin-2 infusion Sprague-Dawley rat model at 3 mg/kg, po and 1 mg/kg, iv | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 9. | ALA3750676 | A | Oral bioavailability in continuous angiotensin 2 infusion Sprague-Dawley rat model at 3 mg/kg | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 10. | ALA3750677 | A | Half life in continuous angiotensin 2 infusion Sprague-Dawley rat model at 3 mg/kg, po and 1 mg/kg, iv | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA3750678 | A | AUC (0 to 24 hrs) in continuous angiotensin 2 infusion Sprague-Dawley rat model at 3 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA3750679 | B | Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assay | Rattus norvegicus | 6 | single protein format | Scientific Literature | ||
| 13. | ALA3750823 | B | Inhibition of CYP11B2 in cynomolgus monkey adrenal homogenates assessed as inhibition of aldosterone secretion | Macaca fascicularis | 4 | tissue-based format | Scientific Literature | ||
| 14. | ALA3750824 | B | Selectivity ratio of IC50 for cynomolgus monkey CYP11B1 to IC50 for cynomolgus monkey CYP11B2 | Macaca fascicularis | 4 | assay format | Scientific Literature | ||
| 15. | ALA3750825 | A | Drug uptake in plasma of po dosed chair-trained chronically cannulated cynomolgus monkey model compound administered followed by ACTH challenge for 3 hrs measured up to 8 hrs post challenge by LC/MS/MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3750826 | A | Drug uptake in plasma of chair-trained chronically cannulated cynomolgus monkey model at 0.03 to 3 mg/kg, po compound administered followed by ACTH challenge for 3 hrs measured at 24 hrs by LC/MS/MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3750827 | F | Decrease in ACTH-stimulated plasma aldosterone level in po dosed chair-trained chronically cannulated cynomolgus monkey model compound administered followed by ACTH challenge for 3 hrs measured after 24 hrs by LC/MS/MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3750828 | F | Decrease in plasma cortisol level in chair-trained chronically cannulated cynomolgus monkey model measured after 24 hrs by LC/MS/MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3750829 | F | Decrease in ACTH-stimulated plasma cortisol level of chair-trained chronically cannulated cynomolgus monkey model at 0.03 to 3 mg/kg, po compound administered followed by ACTH challenge for 24 hrs by LC/MS/MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3750830 | A | Tmax in healthy human at 30 mg/kg, po bid | Homo sapiens | 1 | organism-based format | Scientific Literature |
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