# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3751185 | Binding | Binding affinity to human GKRP by surface plasmon resonance analysis | Homo sapiens | 14 | ALA3745641 | single protein format | Scientific Literature | |
2. | ALA3751186 | Binding | Binding affinity to rat GKRP by surface plasmon resonance analysis | Rattus norvegicus | 10 | ALA3745641 | single protein format | Scientific Literature | |
3. | ALA3751187 | Binding | Binding affinity to mouse GKRP by surface plasmon resonance analysis | Mus musculus | 10 | ALA3745641 | single protein format | Scientific Literature | |
4. | ALA3751188 | ADME | Intrinsic clearance in rat liver microsomes after 30 mins | Rattus norvegicus | 23 | ALA3745641 | tissue-based format | Scientific Literature | |
5. | ALA3751191 | Binding | Inhibition of glucokinase-GKRP binding interaction in mouse hepatocytes assessed as induction of glucokinase translocation | Mus musculus | 23 | ALA3745641 | cell-based format | Scientific Literature | |
6. | ALA3751192 | Binding | Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaScreen assay | Homo sapiens | 24 | ALA3745641 | single protein format | Scientific Literature | |
7. | ALA3751193 | ADME | Apparent permeability from apical to basolateral side in pig LLC-PK1 cells | Sus scrofa | 12 | ALA3745641 | cell-based format | Scientific Literature | |
8. | ALA3751194 | ADME | Efflux ratio of permeability in pig LLC-PK1 cells | Sus scrofa | 9 | ALA3745641 | cell-based format | Scientific Literature | |
9. | ALA3751195 | ADME | Plasma protein binding in rat by rapid equilibrium dialysis method | Rattus norvegicus | 2 | ALA3745641 | cell-free format | Scientific Literature | |
10. | ALA3751196 | ADME | Clearance in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 2 | ALA3745641 | organism-based format | Scientific Literature | |
11. | ALA3751197 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 2 | ALA3745641 | organism-based format | Scientific Literature | |
12. | ALA3751198 | ADME | Half life in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 2 | ALA3745641 | organism-based format | Scientific Literature | |
13. | ALA3751199 | ADME | Cmax in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA3745641 | organism-based format | Scientific Literature | |
14. | ALA3751200 | ADME | Tmax in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA3745641 | organism-based format | Scientific Literature | |
15. | ALA3751201 | ADME | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg | Rattus norvegicus | 2 | ALA3745641 | organism-based format | Scientific Literature | |
16. | ALA3751202 | Functional | Induction of glucokinase translocation in Sprague-Dawley rat at 10 and 100 mg/kg, po qd after 24 hrs | Rattus norvegicus | 1 | ALA3745641 | organism-based format | Scientific Literature | |
17. | ALA3751203 | ADME | Drug uptake in po dosed Sprague-Dawley rat plasma administered qd measured after 6 hrs | Rattus norvegicus | 2 | ALA3745641 | organism-based format | Scientific Literature | |
18. | ALA3751204 | ADME | Plasma concentration in Sprague-Dawley rat at 10 mg/kg, po qd at 24 hrs | Rattus norvegicus | 2 | ALA3745641 | organism-based format | Scientific Literature | |
19. | ALA3751205 | ADME | Plasma concentration in Sprague-Dawley rat at 100 mg/kg, po qd at 24 hrs | Rattus norvegicus | 2 | ALA3745641 | organism-based format | Scientific Literature | |
20. | ALA3751334 | ADME | Drug uptake in db/db mouse blood at 100 mg/kg, po qd after 6 hrs | Mus musculus | 2 | ALA3745641 | organism-based format | Scientific Literature |