# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3748118 | B | Antagonist activity at human platelet P2Y12 receptor assessed as inhibition of ADP-mediated decrease in intra-platelet phosphorylated VASP by FLUO-4 staining based flow cytometric analysis | Homo sapiens | 16 | ALA3745686 | assay format | Scientific Literature | |
2. | ALA3748119 | B | Agonist activity at human platelet P2X1 receptor assessed as increase in cytosolic calcium level at 1 uM by FLURO-4 staining based flow cytometric analysis relative to beta,gamma-CH2-ATP | Homo sapiens | 18 | ALA3745686 | assay format | Scientific Literature | |
3. | ALA3748120 | F | Anti-aggregatory activity in human platelet rich plasma assessed as inhibition of ADP-induced primary and secondary platelet aggregation preincubated for 15 mins followed by ADP addition and 10 secs shaking measured every 27 secs with 10 secs shaking by 96- well microplate method | Homo sapiens | 1 | ALA3745686 | cell-free format | Scientific Literature | |
4. | ALA3748121 | F | Anti-aggregatory activity in human platelet rich plasma assessed as inhibition of 3 uM ADP-induced platelet aggregation measured every 11 secs for 6 mins by 96- well microplate method | Homo sapiens | 16 | ALA3745686 | cell-free format | Scientific Literature | |
5. | ALA3748122 | F | Anti-aggregatory activity in human platelet rich plasma assessed as inhibition of 5 uM ADP-induced platelet aggregation preincubated for 15 mins followed by ADP addition measured every 11 secs for 6 mins by 96- well microplate method | Homo sapiens | 16 | ALA3745686 | cell-free format | Scientific Literature | |
6. | ALA3748123 | F | Anti-aggregatory activity in human platelet rich plasma assessed as inhibition of 20 uM ADP-induced platelet aggregation preincubated for 15 mins followed by ADP addition measured every 11 secs for 6 mins by 96- well microplate method | Homo sapiens | 16 | ALA3745686 | cell-free format | Scientific Literature | |
7. | ALA3748124 | F | Antagonist activity at human platelet P2Y1 receptor assessed as inhibition of ADP-induced increase in cytosolic calcium level by FLUO-4 staining based flow cytometric analysis | Homo sapiens | 17 | ALA3745686 | assay format | Scientific Literature | |
8. | ALA3748125 | B | Agonist activity at human platelet P2Y12 receptor assessed as decrease in intra-platelet phosphorylated VASP by FLUO-4 staining based flow cytometric analysis | Homo sapiens | 15 | ALA3745686 | assay format | Scientific Literature | |
9. | ALA3748126 | F | Anti-aggregatory activity in human platelet rich plasma assessed as inhibition of 20 uM ADP-induced platelet aggregation by optical aggregometric analysis | Homo sapiens | 3 | ALA3745686 | cell-free format | Scientific Literature | |
10. | ALA3748127 | F | Anti-aggregatory activity in human platelet rich plasma assessed as inhibition of 20 uM ADP-induced platelet aggregation at 25 nM preincubated for 15 mins followed by ADP addition measured every 11 secs for 6 mins by 96- well microplate method | Homo sapiens | 1 | ALA3745686 | cell-free format | Scientific Literature | |
11. | ALA3748128 | F | Anti-aggregatory activity in human platelet rich plasma assessed as inhibition of 20 uM ADP-induced platelet aggregation at 100 nM preincubated for 15 mins followed by ADP addition measured every 11 secs for 6 mins by 96- well microplate method | Homo sapiens | 1 | ALA3745686 | cell-free format | Scientific Literature | |
12. | ALA3748129 | F | Anti-aggregatory activity in human platelet rich plasma assessed as inhibition of 20 uM ADP-induced platelet surface activated GP2b-3a expression by fluorescence assay | Homo sapiens | 1 | ALA3745686 | cell-free format | Scientific Literature | |
13. | ALA3748130 | F | Anti-aggregatory activity in human platelet rich plasma assessed as inhibition of 20 uM ADP-induced P-selectin expression by fluorescence assay | Homo sapiens | 1 | ALA3745686 | cell-free format | Scientific Literature | |
14. | ALA3748131 | F | Anti-aggregatory activity in ADP-induced human platelet rich plasma assessed as platelet surface activated GP2b-3a expression at 10 nM preincubated for 30 mins followed by 100 fold dilution by fluorescence assay | Homo sapiens | 1 | ALA3745686 | cell-free format | Scientific Literature | |
15. | ALA3748132 | F | Anti-aggregatory activity in ADP-induced human platelet rich plasma assessed as P-selectin expression at 10 nM preincubated for 30 mins followed by 100 fold dilution by fluorescence assay | Homo sapiens | 1 | ALA3745686 | cell-free format | Scientific Literature | |
16. | ALA3748133 | A | Chemical stability in heat denaturated plasma (unknown origin) | Not specified | 1 | ALA3745686 | cell-free format | Scientific Literature | |
17. | ALA3748134 | F | Anti-aggregatory activity in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation by optical aggregometry | Homo sapiens | 1 | ALA3745686 | cell-free format | Scientific Literature | |
18. | ALA3748135 | A | Drugmetabolism in human plasma assessed as MeSAMP(S) formation at 50 uM after 77 hrs by HPLC analysis | Homo sapiens | 1 | ALA3745686 | cell-free format | Scientific Literature | |
19. | ALA3748136 | A | Drug metabolism in human plasma assessed as MeSAdo formation at 50 uM after 77 hrs by HPLC analysis | Homo sapiens | 1 | ALA3745686 | cell-free format | Scientific Literature | |
20. | ALA3748137 | A | Drug metabolism in rat plasma assessed as MeSAMP(S) formation at 50 uM after 77 hrs by HPLC analysis | Rattus norvegicus | 1 | ALA3745686 | cell-free format | Scientific Literature |