# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3750202 | A | Stability of the compound in human plasma after 4 hrs at 37 degC by mass spectrometric analysis | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
2. | ALA3750336 | B | Induction of bovine LPL stabilization using intralipid as substrate preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate addition measured after 45 mins relative to control | Bos taurus | 3 | single protein format | Scientific Literature | ||
3. | ALA3750337 | F | Hypolipidemic activity in C57B16/J mouse assessed as reduction in plasma triglyceride level at 10 mg/kg, ip qd administered for 4 days followed by olive oil injection through oral gavage one hour post last dose measured at 60 to 120 mins relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
4. | ALA3750338 | F | Hypolipidemic activity in C57B16/J mouse assessed as reduction in plasma triglyceride level at 10 mg/kg, ip qd administered for 4 days followed by olive oil injection through oral gavage one hour post last dose measured at 180 mins | Mus musculus | 6 | organism-based format | Scientific Literature | ||
5. | ALA3748104 | P | Kinetic aqueous solubility of the compound in PBS at pH 7.4 after 2 hrs by LC-MS/MS analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA3748105 | B | Induction of bovine LPL stabilization using intralipid as substrate at 3.12 uM preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate addition measured after 45 mins relative to control | Bos taurus | 61 | single protein format | Scientific Literature | ||
7. | ALA3748106 | B | Induction of bovine LPL stabilization using intralipid as substrate at 6.25 uM preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate addition measured after 45 mins relative to control | Bos taurus | 61 | single protein format | Scientific Literature | ||
8. | ALA3748107 | B | Induction of bovine LPL stabilization using intralipid as substrate at 12.5 uM preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate addition measured after 45 mins relative to control | Bos taurus | 61 | single protein format | Scientific Literature | ||
9. | ALA3748108 | B | Induction of bovine LPL stabilization using intralipid as substrate at 25 uM preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate addition measured after 45 mins relative to control | Bos taurus | 61 | single protein format | Scientific Literature | ||
10. | ALA3748109 | A | Half life in human plasma after 24 hrs | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
11. | ALA3748110 | A | Drug metabolism in human plasma assessed as 2-((4-(Piperidin-1-yl)-3-(p-tolylcarbamoyl)phenyl)carbamoyl)terephthalic acid formation at 10 uM after 24 hrs by LC-MS/MS analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
12. | ALA3748111 | A | Drug metabolism in human plasma assessed as 4-((4-(Piperidin-1-yl)-3-(p-tolylcarbamoyl)phenyl)carbamoyl)isophthalic acid formation at 10 uM after 24 hrs by LC-MS/MS analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
13. | ALA3748112 | A | Drug metabolism in human plasma assessed as 5-amino-2-(piperidin-1-yl)-N-p-tolylbenzamide formation at 10 uM after 24 hrs by LC-MS/MS analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
14. | ALA3748114 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM after 15 to 60 mins | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
15. | ALA3748115 | A | Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM after 15 to 60 mins | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
16. | ALA3748116 | A | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in human Caco2 cells at 10 uM after 15 to 60 mins | Homo sapiens | 3 | cell-based format | Scientific Literature |