# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3750201 | A | Fraction unbound in human plasma at 10 uM after 4 hrs by rapid equilibrium dialysis method | Homo sapiens | 2 | ALA3745639 | cell-free format | Scientific Literature | |
2. | ALA3750202 | A | Stability of the compound in human plasma after 4 hrs at 37 degC by mass spectrometric analysis | Homo sapiens | 3 | ALA3745639 | cell-free format | Scientific Literature | |
3. | ALA3750203 | A | Half life in human liver microsomes at 1 uM | Homo sapiens | 2 | ALA3745639 | tissue-based format | Scientific Literature | |
4. | ALA3750204 | A | Intrinsic clearance in human liver microsomes at 1 uM after 5 to 40 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 2 | ALA3745639 | tissue-based format | Scientific Literature | |
5. | ALA3750334 | A | Intrinsic clearance in human hepatocytes assessed per 10'6 cells at 1 uM after 10 to 60 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 2 | ALA3745639 | cell-based format | Scientific Literature | |
6. | ALA3750335 | A | Half life in human hepatocytes at 1 uM | Homo sapiens | 2 | ALA3745639 | cell-based format | Scientific Literature | |
7. | ALA3750338 | F | Hypolipidemic activity in C57B16/J mouse assessed as reduction in plasma triglyceride level at 10 mg/kg, ip qd administered for 4 days followed by olive oil injection through oral gavage one hour post last dose measured at 180 mins | Mus musculus | 6 | ALA3745639 | organism-based format | Scientific Literature | |
8. | ALA3750339 | P | Kinetic aqueous solubility of the compound in PBS at pH 1.2 after 2 hrs by LC-Ms analysis | 2 | ALA3745639 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA3748104 | P | Kinetic aqueous solubility of the compound in PBS at pH 7.4 after 2 hrs by LC-MS/MS analysis | 3 | ALA3745639 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA3748105 | B | Induction of bovine LPL stabilization using intralipid as substrate at 3.12 uM preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate addition measured after 45 mins relative to control | Bos taurus | 61 | ALA3745639 | single protein format | Scientific Literature | |
11. | ALA3748106 | B | Induction of bovine LPL stabilization using intralipid as substrate at 6.25 uM preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate addition measured after 45 mins relative to control | Bos taurus | 61 | ALA3745639 | single protein format | Scientific Literature | |
12. | ALA3748107 | B | Induction of bovine LPL stabilization using intralipid as substrate at 12.5 uM preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate addition measured after 45 mins relative to control | Bos taurus | 61 | ALA3745639 | single protein format | Scientific Literature | |
13. | ALA3748108 | B | Induction of bovine LPL stabilization using intralipid as substrate at 25 uM preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate addition measured after 45 mins relative to control | Bos taurus | 61 | ALA3745639 | single protein format | Scientific Literature | |
14. | ALA3748114 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM after 15 to 60 mins | Homo sapiens | 3 | ALA3745639 | cell-based format | Scientific Literature | |
15. | ALA3748115 | A | Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM after 15 to 60 mins | Homo sapiens | 3 | ALA3745639 | cell-based format | Scientific Literature | |
16. | ALA3748116 | A | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in human Caco2 cells at 10 uM after 15 to 60 mins | Homo sapiens | 3 | ALA3745639 | cell-based format | Scientific Literature |