| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3756649 | P | Partition coefficient, log P of the compound at pH 7.4 by shake flask method | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA3756650 | P | Aqueous solubility of the compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA3756651 | A | Prodrug conversion in Sprague-Dawley rat stomach homogenate assessed as 4-amino-2-hydroxybenzoic acid formation at pH 4.5 by HPLC analysis | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 4. | ALA3756653 | A | Prodrug conversion in Sprague-Dawley rat small intestine homogenate assessed as 4-amino-2-hydroxybenzoic acid formation at pH 6.8 by HPLC analysis | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 5. | ALA3756655 | A | Prodrug conversion in Sprague-Dawley rat cecum assessed as 4-amino-2-hydroxybenzoic acid formation at pH 7.4 after 12 hrs by HPLC analysis | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 6. | ALA3756657 | A | Prodrug conversion in Sprague-Dawley rat colon assessed as 4-amino-2-hydroxybenzoic acid formation at pH 7.4 after 12 hrs by HPLC analysis | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 7. | ALA3756659 | A | Prodrug conversion in colitis Sprague-Dawley rat model stomach homogenate assessed as 4-amino-2-hydroxybenzoic acid formation at pH 4.5 by HPLC analysis | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 8. | ALA3756661 | A | Prodrug conversion in colitis Sprague-Dawley rat model small intestine homogenate assessed as 4-amino-2-hydroxybenzoic acid formation at pH 6.8 by HPLC analysis | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 9. | ALA3756663 | A | Prodrug conversion in colitis Sprague-Dawley rat model cecum assessed as 4-amino-2-hydroxybenzoic acid formation at pH 7.4 after 12 hrs by HPLC analysis | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 10. | ALA3756665 | A | Prodrug conversion in colitis Sprague-Dawley rat model colon assessed as 4-amino-2-hydroxybenzoic acid formation at pH 7.4 after 12 hrs by HPLC analysis | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 11. | ALA3756668 | F | Antiulcerative colitis activity in TNBS-induced Sprague-Dawley rat colitis model at 385 mg/kg, qd for 6 consecutive days measured after 12 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA3756669 | F | Antiulcerative colitis activity in TNBS-induced Sprague-Dawley rat colitis model drug administered for once daily for 6 consecutive days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3756670 | F | Antiulcerative colitis activity in TNBS-induced Sprague-Dawley rat colitis model assessed as decrease in colon/body weight ratio drug administered once daily for 6 consecutive days measured 24 hrs after last drug challenge | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3756845 | F | Antiulcerative colitis activity in TNBS-induced Sprague-Dawley rat colitis model assessed as decrease in macroscopic injury ratio drug administered once daily for 6 consecutive days measured 24 hrs after last drug challenge | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3756846 | F | Antiulcerative colitis activity in TNBS-induced Sprague-Dawley rat colitis model assessed as normal morphology of colon at 385 mg/kg qd for 6 consecutive days by hematoxylin and eosin staining based light microscopic analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3757684 | F | Antiulcerative colitis activity in TNBS-induced Sprague-Dawley rat colitis model assessed as normal morphology of colon at 255 mg/kg qd for 6 consecutive days by hematoxylin and eosin staining based light microscopic analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3757687 | F | Antiulcerative colitis activity in TNBS-induced Sprague-Dawley rat colitis model assessed as myeloperoxidase activity at 385 mg/kg, qd for 6 consecutive days by spectrophotometry (Rvb = 1.44 +/- 0.041 U/g) | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3757688 | F | Antiulcerative colitis activity in TNBS-induced Sprague-Dawley rat colitis model assessed as effect on TNBS-induced mucosal abscess at 128 mg/kg qd for 6 consecutive days by hematoxylin and eosin staining based light microscopic analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3757689 | P | Stability of compound in isotonic phosphate buffer at pH 1.2 after 12 hrs by HPLC analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 20. | ALA3757690 | P | Stability of compound in isotonic phosphate buffer at pH 6.8 after 12 hrs by HPLC analysis | 1 | small-molecule physicochemical format | Scientific Literature |
The page will load shortly, Thanks for your patience!