# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3758059 | F | Cognition improving effect in scopolamine-induced ICR mouse memory impairment model assessed as improvement in pathlength in target quadrant at 20 umol/kg, po qd pretreated for 30 mins measured 30 mins post scopolamine challenge measured on day 6 by Morris water maze test relative to scopolamine | Mus musculus | 2 | ALA3751805 | organism-based format | Scientific Literature | |
2. | ALA3758060 | B | Potency index, ratio of tacrine IC50 to compound IC50 for inhibition of recombinant human AChE | Homo sapiens | 1 | ALA3751805 | single protein format | Scientific Literature | |
3. | ALA3758061 | B | Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method | Homo sapiens | 28 | ALA3751805 | single protein format | Scientific Literature | |
4. | ALA3755060 | B | Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method | Homo sapiens | 28 | ALA3751805 | single protein format | Scientific Literature | |
5. | ALA3755061 | B | Selectivity ratio of IC50 for human serum BChE to IC50 for recombinant human AChE | Homo sapiens | 28 | ALA3751805 | assay format | Scientific Literature | |
6. | ALA3755062 | B | Ratio of rhein-tacrine hybrid IC50 for inhibition of electric eel AChE to compound IC50 for inhibition of recombinant human AChE | 1 | ALA3751805 | assay format | Scientific Literature | ||
7. | ALA3755063 | B | Inhibition of HFIP pretreated Amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 10 uM incubated for 24 hrs by Thioflavin T-based fluorometric assay | Homo sapiens | 28 | ALA3751805 | single protein format | Scientific Literature | |
8. | ALA3755064 | B | Mixed-type inhibition of recombinant human AChE using acetylthiocholine iodide as substrate assessed as enzyme-inhibitor complex by Lineweaver-Burk double reciprocal plot method | Homo sapiens | 1 | ALA3751805 | single protein format | Scientific Literature | |
9. | ALA3755065 | B | Mixed-type inhibition of recombinant human AChE using acetylthiocholine iodide as substrate assessed as enzyme-substrate-inhibitor complex by Lineweaver-Burk double reciprocal plot method | Homo sapiens | 1 | ALA3751805 | single protein format | Scientific Literature | |
10. | ALA3755066 | B | Inhibition of recombinant human AChE assessed as reduction in AChE-induced amyloid beta (1 to 40) aggregation at 100 uM after 24 hrs by thioflavin T fluorescence-based fluorimetric method relative to control | Homo sapiens | 4 | ALA3751805 | single protein format | Scientific Literature | |
11. | ALA3755067 | B | Inhibition of recombinant human BACE-1 using M-2420 as substrate preincubated for 1 hr followed by substrate addition measured after 15 mins by FRET assay | Homo sapiens | 4 | ALA3751805 | single protein format | Scientific Literature | |
12. | ALA3755073 | B | Tight-binding inhibition of Torpedo californica AChE using ATCh as substrate at 1 to 10 nM by stopped flow apparatus method | Torpedo californica | 1 | ALA3751805 | single protein format | Scientific Literature | |
13. | ALA3755074 | B | Tight-binding inhibition of Torpedo californica AChE using ATCh as substrate at 0.3 nM preincubated for 90 mins followed by substrate addition by potentiometric titration method | Torpedo californica | 1 | ALA3751805 | single protein format | Scientific Literature | |
14. | ALA3755075 | B | Competitive inhibition of Torpedo californica AChE using ATCh as substrate assessed as second order association constant preincubated for 90 mins followed by substrate addition by potentiometric titration method | Torpedo californica | 1 | ALA3751805 | single protein format | Scientific Literature | |
15. | ALA3755076 | B | Competitive inhibition of Torpedo californica AChE using ATCh as substrate assessed as dissociation rate constant preincubated for 90 mins followed by substrate addition by potentiometric titration method | Torpedo californica | 1 | ALA3751805 | single protein format | Scientific Literature | |
16. | ALA3755077 | B | Noncompetitive inhibition of Torpedo californica AChE using ATCh as substrate assessed as second order association constant preincubated for 90 mins followed by substrate addition by potentiometric titration method | Torpedo californica | 1 | ALA3751805 | single protein format | Scientific Literature | |
17. | ALA3755078 | B | Noncompetitive inhibition of Torpedo californica AChE using ATCh as substrate assessed as dissociation rate constant preincubated for 90 mins followed by substrate addition by potentiometric titration method | Torpedo californica | 1 | ALA3751805 | single protein format | Scientific Literature | |
18. | ALA3755079 | B | Competitive inhibition of Torpedo californica AChE using ATCh as substrate preincubated for 90 mins followed by substrate addition by potentiometric titration method | Torpedo californica | 1 | ALA3751805 | single protein format | Scientific Literature | |
19. | ALA3755080 | B | Noncompetitive inhibition of Torpedo californica AChE using ATCh as substrate preincubated for 90 mins followed by substrate addition by potentiometric titration method | Torpedo californica | 1 | ALA3751805 | single protein format | Scientific Literature | |
20. | ALA3755081 | A | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability at 3 uM after 48 hrs by MTT assay | Homo sapiens | 2 | ALA3751805 | cell-based format | Scientific Literature |