# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3758061 | B | Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method | Homo sapiens | 28 | ALA3751805 | single protein format | Scientific Literature | |
2. | ALA3755060 | B | Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method | Homo sapiens | 28 | ALA3751805 | single protein format | Scientific Literature | |
3. | ALA3755061 | B | Selectivity ratio of IC50 for human serum BChE to IC50 for recombinant human AChE | Homo sapiens | 28 | ALA3751805 | assay format | Scientific Literature | |
4. | ALA3755063 | B | Inhibition of HFIP pretreated Amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 10 uM incubated for 24 hrs by Thioflavin T-based fluorometric assay | Homo sapiens | 28 | ALA3751805 | single protein format | Scientific Literature | |
5. | ALA3755066 | B | Inhibition of recombinant human AChE assessed as reduction in AChE-induced amyloid beta (1 to 40) aggregation at 100 uM after 24 hrs by thioflavin T fluorescence-based fluorimetric method relative to control | Homo sapiens | 4 | ALA3751805 | single protein format | Scientific Literature | |
6. | ALA3755068 | B | Inhibition of recombinant human BACE-1 using fluorogenic substrate incubated for 30 mins by FRET assay | Homo sapiens | 1 | ALA3751805 | single protein format | Scientific Literature | |
7. | ALA3755072 | B | Inhibition of Amyloid beta (1 to 42) (unknown origin) self-induced aggregation incubated for 24 hrs by Thioflavin T-based fluorometric assay | Homo sapiens | 1 | ALA3751805 | single protein format | Scientific Literature | |
8. | ALA3755655 | T | Hepatotoxicity in ICR mouse assessed as serum alanine aminotransferase level at 30 mg/kg, ig after 8 hrs by spectrophotometry analysis (Rvb = 38.8 +/- 10.1 U/L) | Mus musculus | 2 | ALA3751805 | organism-based format | Scientific Literature | |
9. | ALA3755656 | T | Hepatotoxicity in ICR mouse assessed as serum alanine aminotransferase level at 30 mg/kg, ig after 22 hrs by spectrophotometry analysis (Rvb = 40.1 +/- 9.9 U/L) | Mus musculus | 2 | ALA3751805 | organism-based format | Scientific Literature | |
10. | ALA3755657 | T | Hepatotoxicity in ICR mouse assessed as serum alanine aminotransferase level at 30 mg/kg, ig after 36 hrs by spectrophotometry analysis (Rvb = 38.1 +/- 8.2 U/L) | Mus musculus | 2 | ALA3751805 | organism-based format | Scientific Literature | |
11. | ALA3755840 | T | Hepatotoxicity in ICR mouse assessed as serum aspartate aminotransferase level at 30 mg/kg, ig after 8 hrs by spectrophotometry analysis (Rvb = 113.3 +/- 30 U/L) | Mus musculus | 2 | ALA3751805 | organism-based format | Scientific Literature | |
12. | ALA3755841 | T | Hepatotoxicity in ICR mouse assessed as serum aspartate aminotransferase level at 30 mg/kg, ig after 22 hrs by spectrophotometry analysis (Rvb = 113.9 +/- 31.1 U/L) | Mus musculus | 2 | ALA3751805 | organism-based format | Scientific Literature | |
13. | ALA3755842 | T | Hepatotoxicity in ICR mouse assessed as serum aspartate aminotransferase level at 30 mg/kg, ig after 36 hrs by spectrophotometry analysis (Rvb = 110.6 +/- 23.1 U/L) | Mus musculus | 2 | ALA3751805 | organism-based format | Scientific Literature | |
14. | ALA5233377 | B | Inhibition of mouse brain AChE | Mus musculus | 11 | ALA5233206 | tissue-based format | Scientific Literature | |
15. | ALA5233378 | B | Inhibition of mouse serum BuChE | Mus musculus | 11 | ALA5233206 | cell-free format | Scientific Literature |