| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3756683 | B | Inhibition of Plasmodium falciparum NMT by 7-diethylamine-3-(4'maleimidylphenyl)-4-methylcoumarin based fluorescence assay | Plasmodium falciparum | 25 | assay format | Scientific Literature | ||
| 2. | ALA3756684 | B | Inhibition of human NMT1 by 7-diethylamine-3-(4'maleimidylphenyl)-4-methylcoumarin based fluorescence assay | Homo sapiens | 25 | single protein format | Scientific Literature | ||
| 3. | ALA3756685 | B | Selectivity index, ratio of Ki(app) for human NMT1 to Ki(app) for Plasmodium falciparum NMT | 20 | assay format | Scientific Literature | |||
| 4. | ALA3773952 | B | Binding affinity to Leishmania donovani N-myristoyltransferase by fluorescence analysis | Leishmania donovani | 15 | assay format | Scientific Literature | ||
| 5. | ALA3773953 | B | Binding affinity to human N-myristoyltransferase by fluorescence analysis | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 6. | ALA3773954 | F | Antileishmanial activity against Leishmania donovani MHOM/ET/67/HU3 amastigotes infected in BaLB/c mouse BMDM cells after 72 hrs by Alamar Blue assay | Leishmania donovani | 5 | organism-based format | Scientific Literature | ||
| 7. | ALA3773956 | B | Selectivity index, ratio of Ki for human N-myristoyltransferase to Ki for Leishmania donovani N-myristoyltransferase | 1 | assay format | Scientific Literature | |||
| 8. | ALA4343050 | B | Inhibition of N-terminal TEV cleavage site-fused His6 tagged Leishmania major NMT (11 to 421 residues) expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins by CPM dye based fluorescence assay | Leishmania major | 11 | cell-based format | Scientific Literature | ||
| 9. | ALA4343051 | A | Inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins by CPM dye based fluorescence assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 10. | ALA4343052 | T | Selectivity index, ratio of Ki for inhibition of N-terminal TEV cleavage site-fused His6 tagged human NMT1 (115 to 496 residues) to Ki for inhibition of N-terminal TEV cleavage site-fused His6 tagged Leishmania major NMT (11 to 421 residues) | 8 | assay format | Scientific Literature | |||
| 11. | ALA4343054 | A | Inhibition of human NMT1 N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins by CPM dye based fluorescence assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 12. | ALA4343058 | A | Inhibition of human NMT1 L495M mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins by CPM dye based fluorescence assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 13. | ALA4343060 | A | Inhibition of human NMT1 R295Q/W297F/A452M/L453V/L462V/N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells using GSNKSKPK as substrate in presence of MyrCoA after 30 mins by CPM dye based fluorescence assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 14. | ALA4343069 | T | Selectivity index, ratio of Ki for inhibition of human NMT1 R295Q/W297F/A452M/L453V/L462V/N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells to Ki for inhibition of N-terminal TEV cleavage site-fused His6 tagged Leishmania major NMT (11 to 421 residues) expressed in Escherichia coli Rosetta-2 cells | 3 | cell-based format | Scientific Literature | |||
| 15. | ALA4343070 | T | Selectivity index, ratio of Ki for inhibition of human NMT1 L495M mutant expressed in Escherichia coli Rosetta-2 cells to Ki for inhibition of N-terminal TEV cleavage site-fused His6 tagged Leishmania major NMT (11 to 421 residues) expressed in Escherichia coli Rosetta-2 cells | 3 | cell-based format | Scientific Literature | |||
| 16. | ALA4343071 | T | Selectivity index, ratio of Ki for inhibition of human NMT1 N473H/L495M/Q496L mutant expressed in Escherichia coli Rosetta-2 cells to Ki for inhibition of N-terminal TEV cleavage site-fused His6 tagged Leishmania major NMT (11 to 421 residues) expressed in Escherichia coli Rosetta-2 cells | 3 | cell-based format | Scientific Literature |
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