# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3761673 | B | Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysis | Homo sapiens | 20 | ALA3758174 | cell-based format | Scientific Literature | |
2. | ALA3761674 | B | Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta by EIA method | Homo sapiens | 19 | ALA3758174 | cell-based format | Scientific Literature | |
3. | ALA3761675 | B | Inhibition of mPGES1 in LPS-induced human whole blood assessed as suppression of PGE2 response after 20 to 24 hrs by LC-MS/MS analysis | Homo sapiens | 19 | ALA3758174 | tissue-based format | Scientific Literature | |
4. | ALA3761678 | A | Inhibition of microsomal CYP3A4 (unknown origin) using bufuralol/midazolam/diclofinac as substrate assessed as 1-hydroxybufuralol maleate-d9/alpha-hydroxymidazolam-d4/[13C6]-4-hydroxydiclofinac formation at 10 uM pre-incubated for 10 mins before NADPH addition by LC-MS/MS analysis | Homo sapiens | 8 | ALA3758174 | assay format | Scientific Literature | |
5. | ALA3761679 | A | Time-dependent inhibition of microsomal CYP3A4 (unknown origin) using midazolam as substrate assessed as alpha-hydroxymidazolam-d4 at 10 uM pre-incubated for 12 mins before NADPH addition formation after 30 mins by LC-MS/MS analysis | Homo sapiens | 9 | ALA3758174 | assay format | Scientific Literature | |
6. | ALA3761701 | B | Inhibition of COX in human A549 cells assessed as reduction in PGE2 production | Homo sapiens | 2 | ALA3758174 | cell-based format | Scientific Literature | |
7. | ALA3761702 | B | Inhibition of COX in human whole blood assessed as decrease in TXB2 production | Homo sapiens | 2 | ALA3758174 | tissue-based format | Scientific Literature | |
8. | ALA3761703 | B | Inhibition of COX in human whole blood assessed as decrease in PGF2alpha production | Homo sapiens | 2 | ALA3758174 | tissue-based format | Scientific Literature |