| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3761673 | B | Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysis | Homo sapiens | 20 | ALA3758174 | cell-based format | Scientific Literature | |
| 2. | ALA3761674 | B | Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta by EIA method | Homo sapiens | 19 | ALA3758174 | cell-based format | Scientific Literature | |
| 3. | ALA3761675 | B | Inhibition of mPGES1 in LPS-induced human whole blood assessed as suppression of PGE2 response after 20 to 24 hrs by LC-MS/MS analysis | Homo sapiens | 19 | ALA3758174 | tissue-based format | Scientific Literature | |
| 4. | ALA3761679 | A | Time-dependent inhibition of microsomal CYP3A4 (unknown origin) using midazolam as substrate assessed as alpha-hydroxymidazolam-d4 at 10 uM pre-incubated for 12 mins before NADPH addition formation after 30 mins by LC-MS/MS analysis | Homo sapiens | 9 | ALA3758174 | assay format | Scientific Literature | |
| 5. | ALA3761682 | A | Oral bioavailability in beagle dog at 2 mg/kg after 0.25 to 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 2 | ALA3758174 | organism-based format | Scientific Literature | |
| 6. | ALA3761689 | A | Volume of distribution at steady state in beagle dog at 2 mg/kg,po or 0.5 mg/kg, iv after 0.25 to 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA3758174 | organism-based format | Scientific Literature | |
| 7. | ALA3761690 | A | Clearance in beagle dog at 2 mg/kg,po or 0.5 mg/kg, iv after 0.25 to 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA3758174 | organism-based format | Scientific Literature | |
| 8. | ALA3761691 | A | Tmax in beagle dog at 2 mg/kg,po after 0.25 to 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA3758174 | organism-based format | Scientific Literature | |
| 9. | ALA3761692 | B | Inhibition of COX in human A549 cells assessed as reduction in PGE2 production at 10 uM | Homo sapiens | 11 | ALA3758174 | cell-based format | Scientific Literature | |
| 10. | ALA3761693 | B | Inhibition of COX in human whole blood assessed as decrease in TXB2 production up to 30 uM | Homo sapiens | 11 | ALA3758174 | tissue-based format | Scientific Literature |
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