| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3767264 | B | Antagonist activity at human AKT1-PH domain (1 to 121 residues) assessed as reduction of AKT1-PH interaction with PC/PE/PS/PI(3,4,5)P3 at 50 uM after 30 mins by competitive SPR analysis relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 2. | ALA3767265 | B | Antagonist activity at mouse GRP1-PH domain (1 to 127 residues) assessed as reduction in PI(3,4,5)P3/GRP1-PH interaction at 50 uM after 30 mins by competitive SPR analysis relative to control | Mus musculus | 4 | single protein format | Scientific Literature | ||
| 3. | ALA3767266 | B | Antagonist activity at human BTK-PH domain (2 to 170 residues) assessed as reduction in PI(3,4,5)P3/BTK-PH interaction at 50 uM after 30 mins by competitive SPR analysis relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 4. | ALA3767267 | B | Antagonist activity at human AKT1-PH domain (1 to 121 residues) assessed as reduction of AKT1-PH interaction with PC/PE/PS/PI(3,4,5)P3 after 30 mins by competitive SPR analysis | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 5. | ALA3767268 | B | Antagonist activity at mouse GRP1-PH domain (1 to 127 residues) assessed as reduction in PI(3,4,5)P3/GRP1-PH interaction after 30 mins by competitive SPR analysis | Mus musculus | 4 | single protein format | Scientific Literature | ||
| 6. | ALA3767269 | B | Antagonist activity at human BTK-PH domain (2 to 170 residues) assessed as reduction in PI(3,4,5)P3/BTK-PH interaction after 30 mins by competitive SPR analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 7. | ALA3767270 | B | Antagonist activity at human Tapp1-PH domain (180 to 305 residues) assessed as reduction in PI(3,4)P2/Tapp1-PH interaction after 30 mins by competitive SPR analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 8. | ALA3767271 | B | Antagonist activity at rat PLCdelta1-PH domain assessed as reduction in PI(3,4)P2/PLCdelta1-PH interaction after 30 mins by competitive SPR analysis | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
| 9. | ALA3767423 | B | Antagonist activity at human AKT1-PH domain (1 to 121 residues) assessed as reduction in PI(3,4,5)P3/AKT1-PH interaction by FRET analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 10. | ALA3767424 | B | Antagonist activity at GST-tagged human AKT1-PH domain (1 to 121 residues) assessed as reduction in PC/PE/PS/PI(3,4,5)P3/AKT1-PH interaction at 50 uM by liposome pull-down assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 11. | ALA3767426 | A | Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation at 1 to 100 uM after 48 hrs by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA3767427 | B | Inhibition of AKT1 phosphorylation at Thr-308 in human MDA-MB-231 cells at 25 uM after 48 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3767428 | A | Effect on membrane fluidity in PC/PE/PS liposome assessed as DPH probe anisotropy changes at 15 uM incubated for 30 mins by fluorescence anisotropic analysis | 5 | assay format | Scientific Literature | |||
| 14. | ALA3767429 | A | Effect on membrane fluidity in PC/PE/PS liposome assessed as NBD-PE probe anisotropy changes at 15 uM incubated for 30 mins by fluorescence anisotropic analysis | 5 | assay format | Scientific Literature | |||
| 15. | ALA3767430 | P | Effect on surface charge of PC/PE/PS/PI(3,4,5)P3 liposome by measuring zeta-potential by light scattering spectrometric analysis | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 16. | ALA3767431 | B | Induction of human AKT1-PH aggregration assessed as mean hydrodynamic diameter after 10 mins dynamic light scattering assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 17. | ALA3767432 | B | Binding affinity to human AKT1-PH domain assessed as change in beta-sheet content at 1:3 molar ratio of protein to compound by CD spectra analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 18. | ALA3767433 | B | Binding affinity to human AKT1-PH domain assessed as enthalpy change by isothermal titration calorimetric analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 19. | ALA3767434 | B | Binding affinity to human AKT1-PH domain assessed as entropy change by isothermal titration calorimetric analysis | Homo sapiens | 2 | single protein format | Scientific Literature |
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