# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3766671 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability at 40 uM after 48 hrs by MTS assay | Homo sapiens | 6 | ALA3763045 | cell-based format | Scientific Literature | |
2. | ALA3766672 | B | Inhibition of HDAC in rat liver at 1 uM by fluorimetry | Rattus norvegicus | 12 | ALA3763045 | assay format | Scientific Literature | |
3. | ALA3766673 | B | Inhibition of recombinant human HDAC2 by fluorimetry | Homo sapiens | 7 | ALA3763045 | single protein format | Scientific Literature | |
4. | ALA3766674 | B | Inhibition of HDAC in rat liver by fluorimetry | Rattus norvegicus | 12 | ALA3763045 | assay format | Scientific Literature | |
5. | ALA3766675 | F | Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability at 40 uM after 48 hrs by MTS assay | Homo sapiens | 6 | ALA3763045 | cell-based format | Scientific Literature | |
6. | ALA3766676 | F | Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTS assay | Homo sapiens | 4 | ALA3763045 | cell-based format | Scientific Literature | |
7. | ALA3766677 | P | Aqueous solubility of the compound in buffer at pH 7.4 after 24 hrs by spectrophotometric method | 14 | ALA3763045 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA3766678 | B | Inhibition of recombinant human HDAC1 by fluorimetry | Homo sapiens | 7 | ALA3763045 | single protein format | Scientific Literature | |
9. | ALA3766679 | B | Inhibition of recombinant human HDAC6 by fluorimetry | Homo sapiens | 7 | ALA3763045 | single protein format | Scientific Literature | |
10. | ALA3766680 | B | Inhibition of recombinant human HDAC8 by fluorimetry | Homo sapiens | 7 | ALA3763045 | single protein format | Scientific Literature | |
11. | ALA3766684 | F | Antiproliferative activity against human HT144 cells assessed as reduction in cell viability at 40 uM after 48 hrs by MTS assay | Homo sapiens | 6 | ALA3763045 | cell-based format | Scientific Literature | |
12. | ALA3766685 | F | Antiproliferative activity against human HT144 cells assessed as reduction in cell viability after 48 hrs by MTS assay | Homo sapiens | 4 | ALA3763045 | cell-based format | Scientific Literature | |
13. | ALA3766843 | P | Chemical stability of the compound in acidic buffer assessed as compound hydrolysis at pH 2 measured for 240 mins by HPLC-PDA analysis | 4 | ALA3763045 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA3766844 | P | Chemical stability of compound in phosphate dibasic buffer assessed as compound degradation at pH 7.4 by HPLC-PDA analysis | 4 | ALA3763045 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA3766845 | P | Chemical stability of the compound in acidic buffer assessed as compound recovery at pH 2 after 4 hrs by HPLC-PDA analysis | 2 | ALA3763045 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA3766847 | P | Lipophilicity, logD of the compound at pH 7.4 after 4 hrs | 2 | ALA3763045 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA3766848 | P | Ionization constant, pKa of the compound in buffer measured over 3 hrs by UV spectrometry | 2 | ALA3763045 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA3766849 | B | Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation at 27 to 54 nM after 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA3763045 | cell-based format | Scientific Literature | |
19. | ALA3766850 | B | Inhibition of HDAC6 in human Calu1 cells assessed as induction of tubulin acetylation at 27 to 54 nM after 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA3763045 | cell-based format | Scientific Literature | |
20. | ALA3766851 | F | Inhibition of cell migration in human Calu1 cells at 27 and 54 nM after 48 hrs by scratch test | Homo sapiens | 1 | ALA3763045 | cell-based format | Scientific Literature |