# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3766477 | B | Inhibition of recombinant human TYK2 kinase domain (885-1176 residues) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 mins by TR-FRET assay | Homo sapiens | 20 | ALA3763089 | single protein format | Scientific Literature | |
2. | ALA3766652 | B | Inhibition of JAK1 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 mins by TR-FRET assay | Homo sapiens | 20 | ALA3763089 | single protein format | Scientific Literature | |
3. | ALA3766653 | B | Inhibition of JAK2 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 mins by TR-FRET assay | Homo sapiens | 20 | ALA3763089 | single protein format | Scientific Literature | |
4. | ALA3766654 | B | Inhibition of JAK3 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 mins by TR-FRET assay | Homo sapiens | 20 | ALA3763089 | single protein format | Scientific Literature | |
5. | ALA3766655 | B | Selectivity ratio of IC50 for JAK1 (unknown origin) to IC50 for recombinant human TYK2 kinase domain (885-1176 residues) | Homo sapiens | 16 | ALA3763089 | assay format | Scientific Literature | |
6. | ALA3766656 | B | Selectivity ratio of IC50 for JAK2 (unknown origin) to IC50 for recombinant human TYK2 kinase domain (885-1176 residues) | Homo sapiens | 16 | ALA3763089 | assay format | Scientific Literature | |
7. | ALA3766657 | B | Selectivity ratio of IC50 for JAK3 (unknown origin) to IC50 for recombinant human TYK2 kinase domain (885-1176 residues) | Homo sapiens | 16 | ALA3763089 | assay format | Scientific Literature | |
8. | ALA3766659 | B | Inhibition of TYK2 in human Jurkat cells assessed as reduction in IL-23-induced luciferase gene expression after 24 hrs | Homo sapiens | 12 | ALA3763089 | cell-based format | Scientific Literature | |
9. | ALA3766660 | A | Clearance in rat at 0.1 mg/kg, iv | Rattus norvegicus | 4 | ALA3763089 | organism-based format | Scientific Literature | |
10. | ALA3766661 | A | Cmax in rat at 1 mg/kg, po | Rattus norvegicus | 4 | ALA3763089 | organism-based format | Scientific Literature | |
11. | ALA3766662 | A | Mean residence time in rat at 1 mg/kg, po | Rattus norvegicus | 4 | ALA3763089 | organism-based format | Scientific Literature | |
12. | ALA3766663 | A | AUC in rat at 1 mg/kg, po | Rattus norvegicus | 4 | ALA3763089 | organism-based format | Scientific Literature | |
13. | ALA3766664 | A | Oral bioavailability in rat at 1 mg/kg | Rattus norvegicus | 4 | ALA3763089 | organism-based format | Scientific Literature |