| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3766477 | B | Inhibition of recombinant human TYK2 kinase domain (885-1176 residues) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 mins by TR-FRET assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
| 2. | ALA3766652 | B | Inhibition of JAK1 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 mins by TR-FRET assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
| 3. | ALA3766653 | B | Inhibition of JAK2 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 mins by TR-FRET assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
| 4. | ALA3766654 | B | Inhibition of JAK3 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 mins by TR-FRET assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
| 5. | ALA3766655 | B | Selectivity ratio of IC50 for JAK1 (unknown origin) to IC50 for recombinant human TYK2 kinase domain (885-1176 residues) | Homo sapiens | 16 | assay format | Scientific Literature | ||
| 6. | ALA3766656 | B | Selectivity ratio of IC50 for JAK2 (unknown origin) to IC50 for recombinant human TYK2 kinase domain (885-1176 residues) | Homo sapiens | 16 | assay format | Scientific Literature | ||
| 7. | ALA3766657 | B | Selectivity ratio of IC50 for JAK3 (unknown origin) to IC50 for recombinant human TYK2 kinase domain (885-1176 residues) | Homo sapiens | 16 | assay format | Scientific Literature | ||
| 8. | ALA3766658 | B | Inhibition of TYK2/JAK2 in human PBMC assessed as reduction in IL-23-induced STAT4 phosphorylation preincubated for 5 mins followed by IL-23 stimulation for 15 to 60 mins by flow cytometry analysis | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 9. | ALA3766659 | B | Inhibition of TYK2 in human Jurkat cells assessed as reduction in IL-23-induced luciferase gene expression after 24 hrs | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 10. | ALA3766660 | A | Clearance in rat at 0.1 mg/kg, iv | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 11. | ALA3766661 | A | Cmax in rat at 1 mg/kg, po | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 12. | ALA3766662 | A | Mean residence time in rat at 1 mg/kg, po | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 13. | ALA3766663 | A | AUC in rat at 1 mg/kg, po | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 14. | ALA3766664 | A | Oral bioavailability in rat at 1 mg/kg | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 15. | ALA3766665 | F | Inhibition of IL-23-induced IL-22 production in po dosed Lewis rat ear administered 30 mins prior to IL-23 injection measured after 24 hrs by ELISA | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3766666 | B | Inhibition of TYK2/JAK1 in human PBMC assessed as reduction in IFNalpha-induced STAT1 phosphorylation preincubated for 5 mins followed by IFNalpha stimulation for 15 to 60 mins by flow cytometry analysis | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 17. | ALA3766667 | B | Inhibition of JAK1/JAK2/TYK2 in human PBMC assessed as reduction in IL-6-induced STAT1 phosphorylation preincubated for 5 mins followed by IL-6 stimulation for 15 to 60 mins by flow cytometry analysis | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 18. | ALA3766668 | B | Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL-21-induced STAT3 phosphorylation preincubated for 5 mins followed by IL-21 stimulation for 15 to 60 mins by flow cytometry analysis | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 19. | ALA3766669 | B | Inhibition of JAK2 in human PBMC assessed as reduction in GM-CSF-induced STAT5 phosphorylation preincubated for 5 mins followed by GM-CSF stimulation for 15 to 60 mins by flow cytometry analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 20. | ALA3766670 | B | Selectivity ratio of IC50 for JAK2 in human PBMC assessed as reduction in GM-CSF-induced STAT5 phosphorylation to IC50 for TYK2/JAK2 in human PBMC assessed as reduction in IL-23-induced STAT4 phosphorylation | Homo sapiens | 1 | assay format | Scientific Literature |
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