# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3767595 | F | Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum relative to (R)-(-)-isoproterenol | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
2. | ALA3767596 | F | Agonist activity at rat beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum relative to (R)-(-)-isoproterenol | Rattus norvegicus | 4 | cell-based format | Scientific Literature | ||
3. | ALA3767597 | F | Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum relative to (R)-(-)-isoproterenol | Macaca mulatta | 4 | cell-based format | Scientific Literature | ||
4. | ALA3767598 | A | Induction of phospholidosis in human HepG2 cells incubated overnight by LDH assay in presence of fluorescent labeled phospholipid probe NBD-PE | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
5. | ALA3767599 | B | Inhibition of human SERT expressed in HEK293 cells preincubated for 30 mins followed by fluorescent substrate addition measured after 30 mins by plate reader analysis | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
6. | ALA3767766 | P | Distribution coefficient, logD of the compound at pH 7.4 | 9 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA3767767 | B | Inhibition of human Nav1.2 channel expressed in Xenopus oocytes by two-intracellular microelectrode voltage clamp method | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
8. | ALA3767768 | B | Displacement of [3H]-diltiazem from human Cav1.2 channel | Homo sapiens | 13 | single protein format | Scientific Literature | ||
9. | ALA3767769 | B | Binding affinity to human ERG channel | Homo sapiens | 13 | single protein format | Scientific Literature | ||
10. | ALA3767770 | A | Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation | Homo sapiens | 8 | tissue-based format | Scientific Literature | ||
11. | ALA3767771 | A | Inhibition of CYP2D6 in human liver microsomes assessed as dextraomethorphan O-demethylation | Homo sapiens | 8 | tissue-based format | Scientific Literature | ||
12. | ALA3767772 | A | Inhibition of CYP2C9 in human liver microsomes assessed as diclofenac alpha'-hydroxylation | Homo sapiens | 8 | tissue-based format | Scientific Literature | ||
13. | ALA3767773 | B | Displacement of [125]I-cyanopindolol from human recombinant beta2 adrenergic receptor after 1 hr by scintillation counting method | Homo sapiens | 13 | single protein format | Scientific Literature | ||
14. | ALA3767774 | B | Displacement of [125]I-cyanopindolol from recombinant human beta1 adrenergic receptor after 1 hr by scintillation counting method | Homo sapiens | 13 | single protein format | Scientific Literature | ||
15. | ALA3768477 | F | Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay relative to (R)-(-)-isoproterenol | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
16. | ALA3768478 | F | Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
17. | ALA3768479 | A | Plasma clearance in rat at 1 mg/kg, iv or 2 mg/kg, po | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
18. | ALA3768480 | A | Plasma clearance in dog at 0.5 mg/kg, iv or 2 mg/kg, po | Canis lupus familiaris | 5 | organism-based format | Scientific Literature | ||
19. | ALA3768481 | A | Stability in human plasma assessed as parent compound remaining at 24 hrs by LC-MS analysis | Homo sapiens | 6 | cell-free format | Scientific Literature | ||
20. | ALA3768482 | A | Plasma clearance in rhesus monkey at 0.5 mg/kg, iv or 2 mg/kg, po | Macaca mulatta | 4 | organism-based format | Scientific Literature |