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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA3767595 Functional Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum relative to (R)-(-)-isoproterenol Homo sapiens 4 ALA3763146 cell-based format Scientific Literature 2. ALA3767596 Functional Agonist activity at rat beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum relative to (R)-(-)-isoproterenol Rattus norvegicus 4 ALA3763146 cell-based format Scientific Literature 3. ALA3767597 Functional Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum relative to (R)-(-)-isoproterenol Macaca mulatta 4 ALA3763146 cell-based format Scientific Literature 4. ALA3767598 ADME Induction of phospholidosis in human HepG2 cells incubated overnight by LDH assay in presence of fluorescent labeled phospholipid probe NBD-PE Homo sapiens 12 ALA3763146 cell-based format Scientific Literature 5. ALA3767599 Binding Inhibition of human SERT expressed in HEK293 cells preincubated for 30 mins followed by fluorescent substrate addition measured after 30 mins by plate reader analysis Homo sapiens 13 ALA3763146 cell-based format Scientific Literature 6. ALA3767766 Physicochemical Distribution coefficient, logD of the compound at pH 7.4 9 ALA3763146 small-molecule physicochemical format Scientific Literature 7. ALA3767767 Binding Inhibition of human Nav1.2 channel expressed in Xenopus oocytes by two-intracellular microelectrode voltage clamp method Homo sapiens 12 ALA3763146 cell-based format Scientific Literature 8. ALA3767768 Binding Displacement of [3H]-diltiazem from human Cav1.2 channel Homo sapiens 13 ALA3763146 single protein format Scientific Literature 9. ALA3767769 Binding Binding affinity to human ERG channel Homo sapiens 13 ALA3763146 single protein format Scientific Literature 10. ALA3767773 Binding Displacement of [125]I-cyanopindolol from human recombinant beta2 adrenergic receptor after 1 hr by scintillation counting method Homo sapiens 13 ALA3763146 single protein format Scientific Literature 11. ALA3767774 Binding Displacement of [125]I-cyanopindolol from recombinant human beta1 adrenergic receptor after 1 hr by scintillation counting method Homo sapiens 13 ALA3763146 single protein format Scientific Literature 12. ALA3768477 Functional Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay relative to (R)-(-)-isoproterenol Homo sapiens 13 ALA3763146 cell-based format Scientific Literature 13. ALA3768478 Functional Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay Homo sapiens 13 ALA3763146 cell-based format Scientific Literature 14. ALA3768479 ADME Plasma clearance in rat at 1 mg/kg, iv or 2 mg/kg, po Rattus norvegicus 7 ALA3763146 organism-based format Scientific Literature 15. ALA3768480 ADME Plasma clearance in dog at 0.5 mg/kg, iv or 2 mg/kg, po Canis lupus familiaris 5 ALA3763146 organism-based format Scientific Literature 16. ALA3768481 ADME Stability in human plasma assessed as parent compound remaining at 24 hrs by LC-MS analysis Homo sapiens 6 ALA3763146 cell-free format Scientific Literature 17. ALA3768482 ADME Plasma clearance in rhesus monkey at 0.5 mg/kg, iv or 2 mg/kg, po Macaca mulatta 4 ALA3763146 organism-based format Scientific Literature 18. ALA3768483 ADME Unbound clearance in rat at 1 mg/kg, iv or 2 mg/kg, po Rattus norvegicus 4 ALA3763146 organism-based format Scientific Literature 19. ALA3768484 ADME Unbound clearance in dog at 0.5 mg/kg, iv or 2 mg/kg, po Canis lupus familiaris 4 ALA3763146 organism-based format Scientific Literature 20. ALA3768485 ADME Unbound clearance in rhesus monkey at 0.5 mg/kg, iv or 2 mg/kg, po Macaca mulatta 4 ALA3763146 organism-based format Scientific Literature