# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3767697 | B | Inhibition of porcine pancreatic lipase at 30 uM | Sus scrofa | 4 | ALA3763072 | single protein format | Scientific Literature | |
2. | ALA3767698 | B | Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellular 2-AG level incubated for 20 mins by LC-MS analysis | Homo sapiens | 7 | ALA3763072 | cell-based format | Scientific Literature | |
3. | ALA3768666 | B | Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-MS analysis | Homo sapiens | 31 | ALA3763072 | cell-based format | Scientific Literature | |
4. | ALA3768672 | B | Inhibition of MAGL (unknown origin) at 30 uM | Homo sapiens | 5 | ALA3763072 | single protein format | Scientific Literature | |
5. | ALA3768871 | A | Permeability coefficient of compound at pH 5.5 after 4 hrs by PAMPA | 10 | ALA3763072 | assay format | Scientific Literature | ||
6. | ALA3768873 | B | Ratio of IC50 for full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells assessed as reduction in intracellular 2-AG level to IC50 for full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane | Homo sapiens | 6 | ALA3763072 | cell-based format | Scientific Literature | |
7. | ALA3768874 | B | Inhibition of DAGLbeta (unknown origin) | Homo sapiens | 6 | ALA3763072 | single protein format | Scientific Literature | |
8. | ALA3768875 | B | Selectivity ratio of IC50 for full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane to IC50 for DAGLbeta (unknown origin) | Homo sapiens | 4 | ALA3763072 | cell-based format | Scientific Literature | |
9. | ALA3768876 | A | Metabolic stability in human liver microsomes assessed as residual compound at 3 uM preincubated for 2 mins followed by NADPH addition measured after 10 mins by LC-MS analysis | Homo sapiens | 4 | ALA3763072 | tissue-based format | Scientific Literature | |
10. | ALA3768877 | A | Metabolic stability in rat liver microsomes assessed as residual compound at 3 uM preincubated for 2 mins followed by NADPH addition measured after 10 mins by LC-MS analysis | Rattus norvegicus | 4 | ALA3763072 | tissue-based format | Scientific Literature | |
11. | ALA3768878 | A | Metabolic stability in mouse liver microsomes assessed as residual compound at 3 uM preincubated for 2 mins followed by NADPH addition measured after 10 mins by LC-MS analysis | Mus musculus | 4 | ALA3763072 | tissue-based format | Scientific Literature | |
12. | ALA3768879 | B | Inhibition of human ERG expressed in HEK293 cells by thallium flux assay | Homo sapiens | 4 | ALA3763072 | cell-based format | Scientific Literature | |
13. | ALA3768880 | A | Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate incubated for 5 mins by LC-MS analysis | Homo sapiens | 4 | ALA3763072 | tissue-based format | Scientific Literature | |
14. | ALA3768881 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 10 mins by LC-MS analysis | Homo sapiens | 4 | ALA3763072 | tissue-based format | Scientific Literature | |
15. | ALA3768882 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 7 mins by LC-MS analysis | Homo sapiens | 4 | ALA3763072 | tissue-based format | Scientific Literature | |
16. | ALA3768883 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 5 mins by LC-MS analysis | Homo sapiens | 4 | ALA3763072 | tissue-based format | Scientific Literature | |
17. | ALA3768884 | A | Transactivation of human PXR expressed in human HepG2 cells after 15 mins by luciferase reporter gene assay | Homo sapiens | 4 | ALA3763072 | cell-based format | Scientific Literature | |
18. | ALA3768885 | A | Half life in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA3763072 | organism-based format | Scientific Literature | |
19. | ALA3768886 | A | Half life in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA3763072 | organism-based format | Scientific Literature | |
20. | ALA3768887 | A | Half life in mouse at 10 mg/kg, ip | Mus musculus | 1 | ALA3763072 | organism-based format | Scientific Literature |