| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3767698 | B | Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells using DAG as substrate assessed as reduction in intracellular 2-AG level incubated for 20 mins by LC-MS analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 2. | ALA3768666 | B | Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-MS analysis | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 3. | ALA3768871 | A | Permeability coefficient of compound at pH 5.5 after 4 hrs by PAMPA | 10 | assay format | Scientific Literature | |||
| 4. | ALA3768873 | B | Ratio of IC50 for full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cells assessed as reduction in intracellular 2-AG level to IC50 for full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 5. | ALA3768876 | A | Metabolic stability in human liver microsomes assessed as residual compound at 3 uM preincubated for 2 mins followed by NADPH addition measured after 10 mins by LC-MS analysis | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
| 6. | ALA3768877 | A | Metabolic stability in rat liver microsomes assessed as residual compound at 3 uM preincubated for 2 mins followed by NADPH addition measured after 10 mins by LC-MS analysis | Rattus norvegicus | 4 | tissue-based format | Scientific Literature | ||
| 7. | ALA3768878 | A | Metabolic stability in mouse liver microsomes assessed as residual compound at 3 uM preincubated for 2 mins followed by NADPH addition measured after 10 mins by LC-MS analysis | Mus musculus | 4 | tissue-based format | Scientific Literature | ||
| 8. | ALA3768879 | B | Inhibition of human ERG expressed in HEK293 cells by thallium flux assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA3768880 | A | Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate incubated for 5 mins by LC-MS analysis | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
| 10. | ALA3768881 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 10 mins by LC-MS analysis | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
| 11. | ALA3768882 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 7 mins by LC-MS analysis | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
| 12. | ALA3768883 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 5 mins by LC-MS analysis | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
| 13. | ALA3768884 | A | Transactivation of human PXR expressed in human HepG2 cells after 15 mins by luciferase reporter gene assay | Homo sapiens | 4 | cell-based format | Scientific Literature |
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