# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3767531 | B | Inhibition of wild type recombinant human EGFR assessed as reduction in autophosphorylation of cytoplasmic domain by Z'-Lyte assay | Homo sapiens | 13 | single protein format | Scientific Literature | ||
2. | ALA3767532 | B | Inhibition of recombinant human EGFR L858R/T790M double mutant assessed as reduction in autophosphorylation of cytoplasmic domain by Z'-Lyte assay | Homo sapiens | 13 | protein format | Scientific Literature | ||
3. | ALA3767533 | B | Potency index, ratio of gefitinib IC50 to compound IC50 for inhibition of recombinant human EGFR L858R/T790M double mutant | Homo sapiens | 4 | protein format | Scientific Literature | ||
4. | ALA3767534 | F | Antiproliferative activity against human A431 cells harboring wild type EGFR assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
5. | ALA3767535 | F | Antiproliferative activity against human HCC827 cells harboring EGFR E746 to A750 deletion mutant assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
6. | ALA3767536 | F | Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
7. | ALA3767537 | F | Antiproliferative activity against human A549 cells harboring K-ras mutation assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
8. | ALA3767538 | F | Antiproliferative activity against human MCF7 cells overexpressing EGFR assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
9. | ALA3767539 | B | Inhibition of EGFR L858R/T790M double mutant autophosphorylation in human NCI-H1975 cells after 12 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA3767540 | B | Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cells assessed as reduction in phosphorylated AKT level at 1 uM after 12 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
11. | ALA3767542 | A | Effect on total EGFR L858R/T790M double mutant level in human NCI-H1975 cells at 0.1 to 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA3767543 | A | Effect on total AKT level in human NCI-H1975 cells at 0.1 to 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA3767544 | A | Effect on total beta-actin level in human NCI-H1975 cells at 0.1 to 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |