| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3768965 | A | Apparent half life in mouse plasma incubated for 6 hrs by UPLC/MC analysis | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 2. | ALA3768966 | F | Antiparasitic activity against Plasmodium falciparum Dd2 assessed as growth inhibition after 72 hrs by DAPI staining-based confocal image analysis | Plasmodium falciparum | 17 | organism-based format | Scientific Literature | ||
| 3. | ALA3768967 | F | Antiparasitic activity against Plasmodium falciparum 3D7 assessed as growth inhibition after 72 hrs by DAPI staining-based confocal image analysis | Plasmodium falciparum | 22 | organism-based format | Scientific Literature | ||
| 4. | ALA3768968 | A | Half life in human liver microsomes at 1 uM by LC/MS analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 5. | ALA3768969 | P | Partition coefficient, log D of the compound at pH 7.4 by HPLC method | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA3768970 | A | Half life in mouse liver microsomes at 1 uM by LC/MS analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 7. | ALA3768971 | P | Kinetic solubility of compound in HCl at pH 2 by nephelometry | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA3768972 | P | Kinetic solubility of compound in phosphate buffer at pH 6.5 by nephelometry | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA3768973 | F | Antiparasitic activity against chloroquine/quinine/pyrimethamine/sulfadoxine/NITD609-resistant Plasmodium falciparum Dd2 clone 2 assessed as growth inhibition after 72 hrs by DAPI staining-based confocal image analysis | Plasmodium falciparum | 17 | organism-based format | Scientific Literature | ||
| 10. | ALA3768974 | B | Inhibition of recombinant Plasmodium falciparum M1 aminopeptidase using H-Leu-NHMec as substrate preincubated for 10 mins followed by addition of substrate by spectrofluorimetric analysis | Plasmodium falciparum | 43 | assay format | Scientific Literature | ||
| 11. | ALA3768975 | A | Cytotoxicity against HEK293 cells assessed as cell viability after 72 hrs by resazurin assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 12. | ALA3768976 | B | Inhibition of recombinant Plasmodium falciparum M17 aminopeptidase using H-Leu-NHMec as substrate preincubated for 10 mins followed by addition of substrate by spectrofluorimetric analysis | Plasmodium falciparum | 43 | assay format | Scientific Literature | ||
| 13. | ALA3768977 | A | Apparent half life in human plasma incubated for 4 hrs by UPLC/MC analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 14. | ALA3768978 | A | Intrinsic clearance in mouse liver microsomes assessed per mg of protein at 1 uM by LC/MS analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA3769148 | A | Intrinsic clearance in human liver microsomes assessed per mg of protein at 1 uM by LC/MS analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 16. | ALA4372767 | B | Inhibition of Plasmodium falciparum C-terminal His6-tagged M1 aminopeptidase (195 to 1085 residues) expressed in Escherichia coli BL21(DE3) preincubated for 20 mins followed by L-leucine-7-amido-4-methylcoumarin addition by Morrison equation analysis | Plasmodium falciparum | 19 | assay format | Scientific Literature | ||
| 17. | ALA4372768 | B | Inhibition of Plasmodium vivax C-terminal His6-tagged M1 aminopeptidase (195 to 1097 residues) expressed in Escherichia coli BL21(DE3) preincubated for 20 mins followed by L-leucine-7-amido-4-methylcoumarin addition by Morrison equation analysis | Plasmodium vivax | 19 | assay format | Scientific Literature | ||
| 18. | ALA4372769 | B | Inhibition of Plasmodium falciparum C-terminal His6-tagged M17 aminopeptidase (85 to 605 residues) expressed in Escherichia coli BL21(DE3) preincubated for 20 mins followed by L-leucine-7-amido-4-methylcoumarin addition by Morrison equation analysis | Plasmodium falciparum | 19 | assay format | Scientific Literature | ||
| 19. | ALA4372770 | B | Inhibition of Plasmodium vivax C-terminal His6-tagged M17 aminopeptidase (203 to 621 residues) expressed in Escherichia coli BL21(DE3) preincubated for 20 mins followed by L-leucine-7-amido-4-methylcoumarin addition by Morrison equation analysis | Plasmodium vivax | 19 | assay format | Scientific Literature | ||
| 20. | ALA4372771 | B | Selectivity ratio of Ki for Plasmodium falciparum C-terminal His6-tagged M1 aminopeptidase (195 to 1085 residues) expressed in Escherichia coli BL21(DE3) to Ki for Plasmodium vivax C-terminal His6-tagged M1 aminopeptidase (195 to 1085 residues) expressed in Escherichia coli BL21(DE3) | 19 | assay format | Scientific Literature |
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