# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3772096 | B | Inhibition of ROCK1 (unknown origin) | Homo sapiens | 6 | ALA3769306 | single protein format | Scientific Literature | |
2. | ALA3772097 | B | Inhibition of ROCK2 (unknown origin) | Homo sapiens | 5 | ALA3769306 | single protein format | Scientific Literature | |
3. | ALA3796494 | B | Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay | Homo sapiens | 50 | ALA3792347 | single protein format | Scientific Literature | |
4. | ALA3796495 | F | Disruption of trabecular meshwork in human TM1 cells assessed as actin fiber length and focal adhesions by Hoechst staining based analysis | Homo sapiens | 50 | ALA3792347 | cell-based format | Scientific Literature | |
5. | ALA3796496 | F | Disruption of trabecular meshwork in porcine Trabecular meshwork cells assessed as actin fiber length and focal adhesions by Hoechst staining based analysis | Sus scrofa | 33 | ALA3792347 | assay format | Scientific Literature | |
6. | ALA3796499 | F | Antiglaucoma activity in Dutch Belted rabbit assessed as decrease in intraocular pressure drug administered 0.1% on day 1 followed 0.2% on day 2 via topical occular instillation measured 4 hrs post dose on day 2 by pneumatonometer | Oryctolagus cuniculus | 1 | ALA3792347 | organism-based format | Scientific Literature | |
7. | ALA3796500 | F | Antiglaucoma activity in Dutch Belted rabbit assessed as decrease in intraocular pressure drug administered 0.1% on day 1 followed 0.2% on day 2 via topical occular instillation measured 8 hrs post dose on day 2 by pneumatonometer | Oryctolagus cuniculus | 1 | ALA3792347 | organism-based format | Scientific Literature | |
8. | ALA3796502 | T | Toxicity in Dutch Belted rabbit assessed as conjunctival hyperemia drug administered 0.1% on day 1 followed 0.2% on day 2 via topical occular instillation | Oryctolagus cuniculus | 7 | ALA3792347 | organism-based format | Scientific Literature | |
9. | ALA3796503 | T | Toxicity in Dutch Belted rabbit assessed as chemosis drug administered 0.1% on day 1 followed 0.2% on day 2 via topical occular instillation | Oryctolagus cuniculus | 7 | ALA3792347 | organism-based format | Scientific Literature | |
10. | ALA3796586 | B | Inhibition of human norepinephrine transporter at 10 uM | Homo sapiens | 4 | ALA3792347 | single protein format | Scientific Literature | |
11. | ALA3796587 | B | Inhibition of human SERT at 10 uM | Homo sapiens | 4 | ALA3792347 | single protein format | Scientific Literature | |
12. | ALA3796588 | A | Inhibition of human CYP2C19 at 10 uM | Homo sapiens | 2 | ALA3792347 | single protein format | Scientific Literature | |
13. | ALA3796589 | A | Inhibition of human CYP2D6 at 10 uM | Homo sapiens | 2 | ALA3792347 | single protein format | Scientific Literature | |
14. | ALA3796590 | A | Inhibition of human CYP3A4 at 10 uM | Homo sapiens | 2 | ALA3792347 | single protein format | Scientific Literature |