# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3772471 | B | Inhibition of bovine brain PDE1 using fluorescent labeled cGMP as substrate after 15 mins by IMAP assay | Bos taurus | 60 | ALA3769405 | assay format | Scientific Literature | |
2. | ALA3772472 | B | Inhibition of recombinant full lenght human PDE10A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay | Homo sapiens | 5 | ALA3769405 | single protein format | Scientific Literature | |
3. | ALA3772473 | B | Inhibition of recombinant full lenght human PDE4A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay | Homo sapiens | 60 | ALA3769405 | single protein format | Scientific Literature | |
4. | ALA3772474 | B | Selectivity ratio of Ki for recombinant full lenght human PDE4A to bovine brain PDE1 | 60 | ALA3769405 | assay format | Scientific Literature | ||
5. | ALA3772476 | B | Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay | Homo sapiens | 5 | ALA3769405 | single protein format | Scientific Literature | |
6. | ALA3772477 | B | Inhibition of recombinant full length human PDE3B using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay | Homo sapiens | 5 | ALA3769405 | single protein format | Scientific Literature | |
7. | ALA3772478 | B | Inhibition of recombinant full lenght human PDE5A using fluorescent labeled cGMP as substrate after 15 mins by IMAP assay | Homo sapiens | 5 | ALA3769405 | single protein format | Scientific Literature | |
8. | ALA3772479 | B | Inhibition of bovine retinal PDE6 using fluorescent labeled cGMP as substrate after 15 mins by IMAP assay | Bos taurus | 5 | ALA3769405 | assay format | Scientific Literature | |
9. | ALA3772480 | B | Inhibition of recombinant full lenght human PDE7B using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay | Homo sapiens | 5 | ALA3769405 | single protein format | Scientific Literature | |
10. | ALA3772481 | B | Inhibition of recombinant full lenght human PDE8A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay | Homo sapiens | 5 | ALA3769405 | single protein format | Scientific Literature | |
11. | ALA3772482 | B | Inhibition of recombinant full lenght human PDE9A using fluorescent labeled cGMP as substrate after 15 mins by IMAP assay | Homo sapiens | 5 | ALA3769405 | single protein format | Scientific Literature | |
12. | ALA3772483 | B | Inhibition of recombinant full lenght human PDE11A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay | Homo sapiens | 5 | ALA3769405 | single protein format | Scientific Literature | |
13. | ALA3772484 | P | Lipophilicity, logD of compound at pH 7.4 | 11 | ALA3769405 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA3772485 | P | Lipophilicity, logD of compound at pH 1.7 | 11 | ALA3769405 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA3772486 | P | Solubility of compound in PBS | 11 | ALA3769405 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA3772633 | A | Cmax in C57BL/6 mouse plasma at 10 mg/kg administered through oral gavage | Mus musculus | 11 | ALA3769405 | organism-based format | Scientific Literature | |
17. | ALA3772634 | A | Cmax in C57BL/6 mouse brain at 10 mg/kg administered through oral gavage | Mus musculus | 11 | ALA3769405 | organism-based format | Scientific Literature | |
18. | ALA3772635 | A | AUClast in C57BL/6 mouse plasma at 10 mg/kg administered through oral gavage | Mus musculus | 11 | ALA3769405 | organism-based format | Scientific Literature | |
19. | ALA3772636 | A | AUClast in C57BL/6 mouse brain at 10 mg/kg administered through oral gavage | Mus musculus | 11 | ALA3769405 | organism-based format | Scientific Literature | |
20. | ALA3772637 | A | Ratio of AUC (0 to 2 hrs) in brain to plasma in C57BL/6 mouse | Mus musculus | 11 | ALA3769405 | cell-free format | Scientific Literature |