# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3773195 | F | Antiviral activity against HCV JFH-1 infected in Huh7.5.1 cells after 48 hrs by luciferase reporter gene assay | Hepacivirus hominis | 51 | ALA3769315 | organism-based format | Scientific Literature | |
2. | ALA3773196 | A | Cytotoxicity against human Huh7.5.1 cells assessed as ATP level by luminescence analysis | Homo sapiens | 51 | ALA3769315 | cell-based format | Scientific Literature | |
3. | ALA3773197 | T | Selectivity index, ratio of CC50 for human Huh7.5.1 cells infected with HCV JFH-1 virus to EC50 for HCV JFH-1 virus | 51 | ALA3769315 | cell-based format | Scientific Literature | ||
4. | ALA3773198 | A | Metabolic stability in rat liver microsomes assessed as half life by LC-MS/MS analysis in presence of NADPH | Rattus norvegicus | 9 | ALA3769315 | tissue-based format | Scientific Literature | |
5. | ALA3773199 | A | Cytotoxicity against human HepG2 cells assessed as ATP level by luminescence analysis | Homo sapiens | 8 | ALA3769315 | cell-based format | Scientific Literature | |
6. | ALA3774135 | A | Cytotoxicity against human primary hepatocytes assessed as ATP level by luminescence analysis | Homo sapiens | 9 | ALA3769315 | cell-based format | Scientific Literature | |
7. | ALA3774136 | A | Inhibition of histamine H1 receptor (unknown origin) assessed as inhibition of histamine-induced beta-arrestin internalization preincubated at 10 nM for 3 hrs followed by addition of 0.25 uM histamine measured after 2 hrs by PathHunter cell based assay | Homo sapiens | 10 | ALA3769315 | cell-based format | Scientific Literature | |
8. | ALA3774137 | F | Antiviral activity against single rounded infectious HCV infected in human Huh7.5.1 cells assessed as viral level at 10 uM after 48 hrs by luciferase reporter gene assay | Hepacivirus hominis | 9 | ALA3769315 | organism-based format | Scientific Literature | |
9. | ALA3774143 | A | Metabolic stability in human liver microsomes assessed as half life by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 7 | ALA3769315 | tissue-based format | Scientific Literature | |
10. | ALA3774144 | A | Metabolic stability in mouse liver microsomes assessed as half life by LC-MS/MS analysis in presence of NADPH | Mus musculus | 7 | ALA3769315 | tissue-based format | Scientific Literature | |
11. | ALA3774146 | P | Solubility of compound in phosphate buffer at pH 7.4 | 9 | ALA3769315 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA3771432 | F | Antiviral activity against HCV genotype 2a assessed as inhibition of RNA replication at 3.2 uM by cell-based replicon assay | Hepacivirus hominis | 2 | ALA3769315 | organism-based format | Scientific Literature | |
13. | ALA3771433 | F | Antiviral activity against single rounded infectious HCV infected in human Huh7.5.1 cells assessed as viral level at 3.2 uM after 48 hrs by luciferase reporter gene assay | Hepacivirus hominis | 2 | ALA3769315 | organism-based format | Scientific Literature | |
14. | ALA3771435 | F | Antiviral activity against HCV genotype 1b pseudoparticle infected in human Huh7.5.1 cells assessed as inhibition of virus entry at 3.2 uM after 4 hrs by luciferase reporter gene assay | Hepacivirus hominis | 2 | ALA3769315 | organism-based format | Scientific Literature | |
15. | ALA3771436 | F | Antiviral activity against HCV genotype 1a pseudoparticle infected in human Huh7.5.1 cells assessed as inhibition of virus entry at 3.2 uM after 4 hrs by luciferase reporter gene assay | Hepacivirus hominis | 2 | ALA3769315 | organism-based format | Scientific Literature | |
16. | ALA3771752 | F | Antiviral activity against Murine leukemia virus pseudoparticle infected in human Huh7.5.1 cells at 3.2 uM after 4 hrs by luciferase reporter gene assay | Murine leukemia virus | 2 | ALA3769315 | organism-based format | Scientific Literature | |
17. | ALA3771754 | F | Antiviral activity against Vesicular stomatitis virus G pseudoparticle infected in human Huh7.5.1 cells at 3.2 uM after 4 hrs by luciferase reporter gene assay | Vesicular stomatitis virus | 2 | ALA3769315 | organism-based format | Scientific Literature | |
18. | ALA3771757 | A | Ratio CC50 for human Huh7.5.1 cells to CC50 for human HepG2 cells | Homo sapiens | 10 | ALA3769315 | cell-based format | Scientific Literature | |
19. | ALA3771758 | A | Ratio CC50 for human Huh7.5.1 cells to CC50 for human primary hepatocytes | Homo sapiens | 10 | ALA3769315 | cell-based format | Scientific Literature |