# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3777092 | ADME | Metabolic stability in dog liver microsomes assessed as parent compound remaining at 10 uM after 2 hrs by HPLC analysis in presence of NADPH | Canis lupus familiaris | 3 | ALA3774381 | tissue-based format | Scientific Literature | |
2. | ALA3777093 | ADME | Metabolic stability in human liver microsomes assessed as parent compound remaining at 10 uM after 2 hrs by HPLC analysis in presence of NADPH | Homo sapiens | 3 | ALA3774381 | tissue-based format | Scientific Literature | |
3. | ALA3777094 | Functional | Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Homo sapiens | 13 | ALA3774381 | cell-based format | Scientific Literature | |
4. | ALA3777095 | Binding | Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HTRF assay | Homo sapiens | 27 | ALA3774381 | single protein format | Scientific Literature | |
5. | ALA3777096 | ADME | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 10 uM after 2 hrs by HPLC analysis in presence of NADPH | Mus musculus | 3 | ALA3774381 | tissue-based format | Scientific Literature | |
6. | ALA3777097 | ADME | Inhibition of CYP3A4 (unknown origin) at 10 uM | Homo sapiens | 3 | ALA3774381 | single protein format | Scientific Literature | |
7. | ALA3777098 | ADME | Inhibition of CYP2C19 (unknown origin) at 10 uM | Homo sapiens | 3 | ALA3774381 | single protein format | Scientific Literature | |
8. | ALA3777099 | ADME | Inhibition of CYP2D6 (unknown origin) at 10 uM | Homo sapiens | 3 | ALA3774381 | single protein format | Scientific Literature | |
9. | ALA3777100 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 3 | ALA3774381 | single protein format | Scientific Literature | |
10. | ALA3777101 | ADME | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 3 | ALA3774381 | single protein format | Scientific Literature | |
11. | ALA3777102 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 3 | ALA3774381 | single protein format | Scientific Literature | |
12. | ALA3777103 | ADME | Tmax in Swiss mouse plasma at 3 mg/kg, po after 0.16 to 8 hrs by LC-MS analysis | Mus musculus | 3 | ALA3774381 | organism-based format | Scientific Literature | |
13. | ALA3777104 | ADME | Cmax in Swiss mouse plasma at 3 mg/kg, po after 0.16 to 8 hrs by LC-MS analysis | Mus musculus | 3 | ALA3774381 | organism-based format | Scientific Literature | |
14. | ALA3777105 | ADME | AUC in Swiss mouse plasma at 3 mg/kg, po after 0.16 to 8 hrs by LC-MS analysis | Mus musculus | 3 | ALA3774381 | organism-based format | Scientific Literature | |
15. | ALA3777106 | ADME | Elimination half life in Swiss mouse plasma at 3 mg/kg, po after 0.16 to 8 hrs by LC-MS analysis | Mus musculus | 3 | ALA3774381 | organism-based format | Scientific Literature |