| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3777120 | B | Inhibition of recombinant GGDPS (unknown origin) assessed as radiolabeled GGPP formation preincubated for 10 mins followed by addition of 10 uM FPP substrate and [14C]IPP for 30 mins by liquid scintillation counter analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 2. | ALA3777121 | B | Inhibition of recombinant FDPS (unknown origin) assessed as radiolabeled FPP formation preincubated for 10 mins followed by addition of 10 uM GPP substrate and [14C]IPP for 30 mins by liquid scintillation counter analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 3. | ALA3777122 | B | Selectivity index, ratio of IC50 for FDPS (unknown origin) to IC50 for GGDPS (unknown origin) | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 4. | ALA3777123 | B | Inhibition of GGDPS in human RPMI8226 cells assessed as disruption of Rap1a geranylation after 48 hrs by immunoblot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA3777124 | B | Inhibition of GGDPS in human RPMI8226 cells assessed as disruption of Rap1a geranylation at 50 nM after 48 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3777125 | F | Cytotoxicity against human RPMI8226 after 48 hrs by MTT assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 7. | ALA4012294 | B | Inhibition of recombinant GGDPS (unknown origin) using FPP as substrate pretreated for 10 mins followed by substrate addition after 30 mins in presence of [14C]-IPP by liquid scintillation counting analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 8. | ALA4012304 | B | Inhibition of GGTase1 in human RPMI8226 cells assessed as decrease in Rap1a geranylgeranylation after 48 hrs by Western blot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4012305 | B | Inhibition of Rab GGTase2 in human RPMI8226 cells assessed as decrease in Rab GTPase geranylgeranylation by measuring accumulation of intracellular lambda light chain after 48 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4012306 | B | Inhibition of Rab GGTase2 in human RPMI8226 cells assessed as decrease in Rab6 geranylgeranylation after 48 hrs by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4182960 | B | Inhibition of recombinant GGDPS (unknown origin) using FPP as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins in presence of [14C]-IPP by liquid scintillation counting method | Homo sapiens | 8 | single protein format | Scientific Literature |
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