| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3778805 | B | Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for 10 mins measured after 20 mins by alphascreen assay | Homo sapiens | 56 | assay format | Scientific Literature | ||
| 2. | ALA3778806 | B | Inhibition of recombinant human N-terminal GST-tagged KDM4B (1 to 500 residues) expressed in baculovirus infected sf9 cells using biotin-H3K9me3 as substrate preincubated for 10 mins measured after 20 mins by alphascreen assay | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
| 3. | ALA3778807 | B | Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by alphascreen assay | Homo sapiens | 56 | single protein format | Scientific Literature | ||
| 4. | ALA3778979 | B | Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by alphascreen assay | Homo sapiens | 54 | single protein format | Scientific Literature | ||
| 5. | ALA3776213 | A | Apparent permeability from apical to basolateral side in human Caco2 cells at 10 uM after 2 hrs by LC-MS/MS analysis | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 6. | ALA3776389 | B | Inhibition of KDM2A (unknown origin) using biotin-H3K36me2 (28 to 48 residues) as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by alphascreen assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 7. | ALA3776390 | B | Inhibition of KDM3A (unknown origin) using biotin-H3K9me2 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate addition measured after 5 mins by alphascreen assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 8. | ALA3776393 | B | Inhibition of KDM6B (unknown origin) using biotin-H3K27me3 (21 to 44 residues) as substrate at 100 uM preincubated for 15 mins followed by substrate addition measured after 5 mins by alphascreen assay relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 9. | ALA3776394 | A | Drug metabolism in human liver microsomes assessed as aldehyde oxidase-mediated compound metabolism at 1 uM after 30 mins by LC-MS/MS analysis in presence of NADPH and UDPGA | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 10. | ALA3776395 | A | Drug metabolism in human liver microsomes assessed as CYP450-mediated compound metabolism at 1 uM after 30 mins by LC-MS/MS analysis in presence of NADPH and UDPGA | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 11. | ALA3776396 | A | Drug metabolism in mouse liver microsomes assessed as aldehyde oxidase-mediated compound metabolism at 1 uM after 30 mins by LC-MS/MS analysis in presence of NADPH and UDPGA | Mus musculus | 3 | tissue-based format | Scientific Literature | ||
| 12. | ALA3776397 | A | Drug metabolism in mouse liver microsomes assessed as CYP450-mediated compound metabolism at 1 uM after 30 mins by LC-MS/MS analysis in presence of NADPH and UDPGA | Mus musculus | 3 | tissue-based format | Scientific Literature | ||
| 13. | ALA3776400 | B | Inhibition of full length N-terminal FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 level after 24 hrs by DAPI staining based immunofluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3776401 | B | Inhibition of full length N-terminal FLAG-tagged KDM5B (unknown origin) expressed in human HeLa cells assessed as increase in H3K4me3 level after 24 hrs by DAPI staining based immunofluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA3776403 | B | Inhibition of full length N-terminal FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as global hypomethylation after 24 hrs by DAPI staining based immunofluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3776404 | B | Inhibition of full length N-terminal FLAG-tagged KDM5B (unknown origin) expressed in human HeLa cells assessed as global hypomethylation after 24 hrs by DAPI staining based immunofluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3776407 | B | Inhibition of human AMPK at 1 uM by radioactive [33P]-ATP filter binding assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 18. | ALA3776408 | B | Inhibition of human Aurora B (1 to 344 residues) at 1 uM by radioactive [33P]-ATP filter binding assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA3776409 | B | Inhibition of human CAMKKB at 1 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA3776410 | B | Inhibition of human CAMK1 at 1 uM | Homo sapiens | 1 | single protein format | Scientific Literature |
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