| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3778237 | B | Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addition measured after 20 mins by HTRF assay | Homo sapiens | 44 | ALA3774350 | assay format | Scientific Literature | |
| 2. | ALA3778238 | B | Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after 20 mins by HTRF assay | Homo sapiens | 44 | ALA3774350 | cell-based format | Scientific Literature | |
| 3. | ALA3778239 | B | Selectivity ratio of IC50 for recombinant His-tagged human KDR expressed in insect Sf21 cells to IC50 for human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system | Homo sapiens | 44 | ALA3774350 | cell-based format | Scientific Literature | |
| 4. | ALA3778240 | B | Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based luminescence assay | Homo sapiens | 35 | ALA3774350 | cell-based format | Scientific Literature | |
| 5. | ALA3778241 | B | Inhibition of KDR (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based luminescence assay | Homo sapiens | 35 | ALA3774350 | cell-based format | Scientific Literature | |
| 6. | ALA3776063 | B | Selectivity ratio of IC50 for KDR inhibition (unknown origin) expressed in mouse BA/F3 cells to IC50 for KIF5B/RET inhibition (unknown origin) expressed in mouse BA/F3 cells | Homo sapiens | 35 | ALA3774350 | cell-based format | Scientific Literature | |
| 7. | ALA3776064 | A | Intrinsic clearance in iv dosed CD1 mouse assessed per 10'6 cells by LC-MS/MS analysis | Mus musculus | 11 | ALA3774350 | organism-based format | Scientific Literature | |
| 8. | ALA3776065 | A | Cytotoxicity in mouse BA/F3 cells after 48 hrs by Cell titre glo-based luminescence assay | Mus musculus | 11 | ALA3774350 | cell-based format | Scientific Literature | |
| 9. | ALA3776066 | A | Oral bioavailability in CD1 mouse by LC-MS/MS analysis | Mus musculus | 1 | ALA3774350 | organism-based format | Scientific Literature | |
| 10. | ALA3776067 | A | Half life in orally dosed CD1 mouse by LC-MS/MS analysis | Mus musculus | 1 | ALA3774350 | organism-based format | Scientific Literature | |
| 11. | ALA3776068 | A | Intrinsic clearance in human liver microsomes by LC-MS/MS analysis | Homo sapiens | 1 | ALA3774350 | tissue-based format | Scientific Literature | |
| 12. | ALA3776069 | A | Intrinsic clearance in CD1 mouse liver microsomes by LC-MS/MS analysis | Mus musculus | 1 | ALA3774350 | tissue-based format | Scientific Literature | |
| 13. | ALA3776070 | A | Intrinsic clearance in CD1 mouse hepatocytes assessed per 10'6 cells by LC-MS/MS analysis | Mus musculus | 1 | ALA3774350 | cell-based format | Scientific Literature | |
| 14. | ALA3776071 | P | Aqueous solubility of compound by LC-MS/MS analysis | 1 | ALA3774350 | small-molecule physicochemical format | Scientific Literature | ||
| 15. | ALA3776072 | A | Apparent permeability in human Caco2 cells | Homo sapiens | 1 | ALA3774350 | cell-based format | Scientific Literature | |
| 16. | ALA3776073 | A | Efflux ratio of permeability in human Caco2 cells | Homo sapiens | 1 | ALA3774350 | cell-based format | Scientific Literature | |
| 17. | ALA3804157 | B | Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15 mins followed by substrate addition measured after 20 mins by FRET assay | Homo sapiens | 42 | ALA3797122 | assay format | Scientific Literature | |
| 18. | ALA3804158 | B | Selectivity ratio for N-terminal GST fused human RET (658 to 1114 amino acid residue) expressed in baculovirus over KDR (unknown origin) | Homo sapiens | 42 | ALA3797122 | assay format | Scientific Literature | |
| 19. | ALA3804159 | B | Inhibition of recombinant KIF5B/RET (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay | Homo sapiens | 42 | ALA3797122 | cell-based format | Scientific Literature | |
| 20. | ALA3804160 | B | Inhibition of recombinant KDR (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay | Homo sapiens | 42 | ALA3797122 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!