# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3782470 | B | Antagonist activity at CXCR4 expressed in human U373-MAGI cells assessed as inhibition of HIV1 gp120-induced cell-cell fusion between HIV1 NL4-3 envelope expressing HEK293T cells to CXCR4 expressing human U373-MAGI cells incubated for 6 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA3779779 | cell-based format | Scientific Literature | |
2. | ALA3802804 | B | Inhibition of CXCR4 mutant (unknown origin) co-transfected in human U373-MAGI cells assessed as reduction of interaction with HIV-1 NL4 to 3 glycoprotein expressed in human 293T cells after 6 hrs by Bright-Glo luciferase assay | Homo sapiens | 1 | ALA3797033 | cell-based format | Scientific Literature | |
3. | ALA3802805 | F | Antagonist activity against CXCR4 in in human MOLT4 cells assessed as inhibition of SDF1alpha -induced Ca2+ mobilization after 30 mins by FACS analysis | Homo sapiens | 1 | ALA3797033 | cell-based format | Scientific Literature | |
4. | ALA3802806 | F | Antiviral activity against HIV1 NL4-3 X4 infected in human MT4 cells assessed as suppression of viral replication after 5 days by MTT assay | Human immunodeficiency virus 1 | 1 | ALA3797033 | organism-based format | Scientific Literature | |
5. | ALA4132835 | F | Antagonist activity at CXCR4 in human MOLT-4 cells assessed as decrease in SDF-1alpha induced cytosolic Ca2+ levels preincubated for 30 mins followed by SDF-1alpha addition by FACS analysis | Homo sapiens | 1 | ALA4130393 | cell-based format | Scientific Literature | |
6. | ALA5261130 | B | Inhibition of human recombinant CXCR4 expressed in THP-1 cells | Homo sapiens | 5 | ALA5260798 | cell-based format | Scientific Literature |