# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3789346 | A | Fraction unbound in rat plasma | Rattus norvegicus | 5 | ALA3784976 | cell-free format | Scientific Literature | |
2. | ALA3789590 | B | Antagonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of AITC-induced Ca2+ influx preincubated for 2 mins followed by AITC addition measured for 2 mins by Fluo-4 dye based FLIPR assay | Homo sapiens | 34 | ALA3784976 | cell-based format | Scientific Literature | |
3. | ALA3789591 | B | Antagonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of AITC-induced Ca2+ influx preincubated for 2 mins followed by AITC addition measured for 2 mins by Fluo-4 dye based FLIPR assay | Rattus norvegicus | 34 | ALA3784976 | cell-based format | Scientific Literature | |
4. | ALA3789592 | A | Apparent intrinsic clearance in rat liver microsomes | Rattus norvegicus | 34 | ALA3784976 | tissue-based format | Scientific Literature | |
5. | ALA3789593 | A | Apparent intrinsic clearance in human liver microsomes | Homo sapiens | 34 | ALA3784976 | tissue-based format | Scientific Literature | |
6. | ALA3791635 | B | Antagonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of AITC-induced 45Ca2+ uptake preincubated for 1 min followed by AITC addition measured after 12 mins | Rattus norvegicus | 7 | ALA3784976 | cell-based format | Scientific Literature | |
7. | ALA3791636 | B | Antagonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of AITC-induced 45Ca2+ uptake preincubated for 1 min followed by AITC addition measured after 12 mins | Homo sapiens | 7 | ALA3784976 | cell-based format | Scientific Literature | |
8. | ALA3791637 | B | Agonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assay | Rattus norvegicus | 7 | ALA3784976 | cell-based format | Scientific Literature | |
9. | ALA3791638 | B | Agonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assay | Homo sapiens | 7 | ALA3784976 | cell-based format | Scientific Literature | |
10. | ALA3791639 | A | Clearance in rat at 0.5 mg/kg, iv as single dose | Rattus norvegicus | 5 | ALA3784976 | organism-based format | Scientific Literature | |
11. | ALA3791641 | A | Volume of distribution at steady state in rat at 0.5 mg/kg, iv as single dose | Rattus norvegicus | 5 | ALA3784976 | organism-based format | Scientific Literature | |
12. | ALA3791642 | A | Half life in rat at 0.5 mg/kg, iv administered as single dose | Rattus norvegicus | 5 | ALA3784976 | organism-based format | Scientific Literature | |
13. | ALA3789637 | A | AUC (infinity) in rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA3784976 | organism-based format | Scientific Literature | |
14. | ALA3789638 | A | fCmax in rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA3784976 | organism-based format | Scientific Literature | |
15. | ALA3789639 | A | Tmax in rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA3784976 | organism-based format | Scientific Literature | |
16. | ALA3789640 | A | Half life in rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA3784976 | organism-based format | Scientific Literature | |
17. | ALA3789641 | A | Cmax in rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA3784976 | organism-based format | Scientific Literature | |
18. | ALA3789642 | U | Ratio of fCmax in rat at 10 mg/kg, po to IC50 for rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells by 45Ca2+ uptake assay | Rattus norvegicus | 1 | ALA3784976 | organism-based format | Scientific Literature |