# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3789200 | B | Inhibition of recombinant full length FLAG-tagged KDM5A (unknown origin) expressed in sf9 cells using biotin-H3K4me3 (1 to 21 residues as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by mass spetcrometric analysis | Homo sapiens | 5 | ALA3784917 | cell-based format | Scientific Literature | |
2. | ALA3789203 | B | Inhibition of KDM5A in human PC9 cells assessed as reduction in demethylation of H3K4me3 after 120 hrs by AlphaLisa assay | Homo sapiens | 2 | ALA3784917 | cell-based format | Scientific Literature | |
3. | ALA3789204 | B | Inhibition of KDM5B in human PC9 cells assessed as reduction in demethylation of H3K4me3 after 120 hrs by AlphaLisa assay | Homo sapiens | 2 | ALA3784917 | cell-based format | Scientific Literature | |
4. | ALA4427145 | P | Octanol-aqueous buffer distribution coefficient, log D of the compound at pH 7.4 | 10 | ALA4425149 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4427147 | B | Inhibition of KDM5A (unknown origin) | Homo sapiens | 43 | ALA4425149 | single protein format | Scientific Literature | |
6. | ALA4427148 | B | Inhibition of KDM5 in human PC9 cells assessed as demethylation of H3K4Me3 | Homo sapiens | 43 | ALA4425149 | cell-based format | Scientific Literature | |
7. | ALA4427149 | A | Protein binding in human plasma | Homo sapiens | 11 | ALA4425149 | cell-free format | Scientific Literature | |
8. | ALA4427150 | A | Apparent permeability across apical to basolateral side in MDCK cells | Canis lupus familiaris | 10 | ALA4425149 | cell-based format | Scientific Literature | |
9. | ALA4427152 | A | Clearance in human liver microsomes | Homo sapiens | 4 | ALA4425149 | microsome format | Scientific Literature | |
10. | ALA4427153 | A | Clearance in rat liver microsomes | Rattus norvegicus | 4 | ALA4425149 | microsome format | Scientific Literature | |
11. | ALA4427154 | A | Clearance in mouse liver microsomes | Mus musculus | 4 | ALA4425149 | microsome format | Scientific Literature | |
12. | ALA4427155 | A | Clearance in human hepatocytes | Homo sapiens | 4 | ALA4425149 | cell-based format | Scientific Literature | |
13. | ALA4427156 | A | Clearance in rat hepatocytes | Rattus norvegicus | 4 | ALA4425149 | cell-based format | Scientific Literature | |
14. | ALA4427157 | A | Clearance in mouse hepatocytes | Mus musculus | 4 | ALA4425149 | cell-based format | Scientific Literature | |
15. | ALA4427158 | A | Clearance in CD-1 mouse plasma at 1 mg/kg, iv or 5 mg/kg, po | Mus musculus | 4 | ALA4425149 | organism-based format | Scientific Literature | |
16. | ALA4427159 | A | Half life in CD-1 mouse at 1 mg/kg, iv or 5 mg/kg, po | Mus musculus | 4 | ALA4425149 | organism-based format | Scientific Literature | |
17. | ALA4427160 | A | Volume of distribution in CD-1 mouse at 1 mg/kg, iv or 5 mg/kg, po | Mus musculus | 4 | ALA4425149 | organism-based format | Scientific Literature | |
18. | ALA4427161 | A | Oral bioavailability in CD-1 mouse at 5 mg/kg | Mus musculus | 4 | ALA4425149 | organism-based format | Scientific Literature | |
19. | ALA4427162 | B | Inhibition of KDM5B (unknown origin) | Homo sapiens | 1 | ALA4425149 | single protein format | Scientific Literature | |
20. | ALA4427163 | B | Inhibition of KDM5C (unknown origin) | Homo sapiens | 1 | ALA4425149 | single protein format | Scientific Literature |