# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3789255 | A | Inhibition of CYP2B6 in human liver microsomes at 10 uM using bupropion as substrate by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 3 | ALA3784928 | tissue-based format | Scientific Literature | |
2. | ALA3789256 | B | Inhibition of CYP26A1-mediated atRA metabolism in human HepG2 cells assessed as atRA level in cell media at 1 uM after 24 hrs in presence of 100 nM atRA by LC/MS-MS analysis (Rvb = 13.2 +/- 0.14 nM) | Homo sapiens | 3 | ALA3784928 | cell-based format | Scientific Literature | |
3. | ALA3789257 | B | Inhibition of CYP26A1 in human HepG2 cells assessed as upregulation of CYP26A1 mRNA expression at 1 uM after 24 hrs in presence of 100 nM atRA by RT-PCR method | Homo sapiens | 3 | ALA3784928 | cell-based format | Scientific Literature | |
4. | ALA3789258 | B | Inhibition of CYP26A1 in human HepG2 cells assessed as upregulation of RARbeta mRNA expression at 1 uM after 24 hrs in presence of 100 nM atRA by RT-PCR method | Homo sapiens | 3 | ALA3784928 | cell-based format | Scientific Literature | |
5. | ALA3789259 | A | Inhibition of CYP2C19 in human liver microsomes at 10 uM using (S)-mephenytoin as substrate by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 3 | ALA3784928 | tissue-based format | Scientific Literature | |
6. | ALA3789260 | A | Inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 3 | ALA3784928 | tissue-based format | Scientific Literature | |
7. | ALA3789261 | A | Inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 3 | ALA3784928 | tissue-based format | Scientific Literature | |
8. | ALA3789263 | B | Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase | Homo sapiens | 24 | ALA3784928 | cell-based format | Scientific Literature | |
9. | ALA3789264 | B | Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 1 min by HPLC analysis in presence of rat P450 reductase | Homo sapiens | 24 | ALA3784928 | cell-based format | Scientific Literature | |
10. | ALA3789266 | A | Inhibition of CYP3A4 in human liver microsomes upto 100 uM using midazolam as substrate by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3784928 | tissue-based format | Scientific Literature | |
11. | ALA3789267 | B | Selectivity ratio of IC50 for microsomal fraction of human CYP26B1 to IC50 for microsomal fraction of human CYP26A1 | Homo sapiens | 4 | ALA3784928 | assay format | Scientific Literature | |
12. | ALA3789268 | B | Activation of human RARalpha at 1 uM by luciferase reporter gene assay | Homo sapiens | 3 | ALA3784928 | single protein format | Scientific Literature | |
13. | ALA3789269 | B | Activation of human RARbeta at 1 uM by luciferase reporter gene assay | Homo sapiens | 3 | ALA3784928 | single protein format | Scientific Literature | |
14. | ALA3789270 | B | Activation of RAR in human HepG2 cells assessed as upregulation of RARbeta mRNA expression at 1 uM after 24 hrs by RT-PCR method | Homo sapiens | 3 | ALA3784928 | cell-based format | Scientific Literature | |
15. | ALA3789271 | B | Activation of RAR in human HepG2 cells assessed as upregulation of CYP26A1 mRNA expression at 1 uM after 24 hrs by RT-PCR method | Homo sapiens | 3 | ALA3784928 | cell-based format | Scientific Literature | |
16. | ALA3789272 | B | Inhibition of CYP26A1-mediated atRA metabolism in human HepG2 cells assessed as atRA level in cell media at 1 uM after 24 hrs in presence of 100 nM atRA by LC/MS-MS analysis relative to atRA-treated control | Homo sapiens | 3 | ALA3784928 | cell-based format | Scientific Literature | |
17. | ALA3789273 | B | Inhibition of CYP26A1-mediated atRA metabolism in human HepG2 cells assessed as atRA level in cell media at 1 uM after 24 hrs by LC/MS-MS analysis (Rvb = 0.49 +/- 0.33 nM) | Homo sapiens | 2 | ALA3784928 | cell-based format | Scientific Literature |