# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3791603 | B | Inhibition of wild type ALK (unknown origin) after 30 mins by HTRF assay | Homo sapiens | 21 | ALA3784918 | single protein format | Scientific Literature | |
2. | ALA3791604 | B | Inhibition of ALK L1196M mutant (unknown origin) after 30 mins by HTRF assay | Homo sapiens | 21 | ALA3784918 | single protein format | Scientific Literature | |
3. | ALA3791605 | B | Inhibition of EML4-ALK in human NCI-H3122 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay | Homo sapiens | 21 | ALA3784918 | cell-based format | Scientific Literature | |
4. | ALA3791606 | B | Inhibition of ALK L1196M mutant in mouse BA/F3 cells assessed as inhibition of cell proliferation after 72 hrs by WST1 assay | Mus musculus | 21 | ALA3784918 | cell-based format | Scientific Literature | |
5. | ALA3791607 | A | Metabolic stability of the compound in human liver microsomes assessed as compound remaining at 1 uM after 30 mins by LC/MS/MS analysis in the presence of NADPH | Homo sapiens | 2 | ALA3784918 | tissue-based format | Scientific Literature | |
6. | ALA3791608 | A | Metabolic stability of the compound in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins by LC/MS/MS analysis in the presence of NADPH | Mus musculus | 2 | ALA3784918 | tissue-based format | Scientific Literature | |
7. | ALA3789027 | A | Tmax in cannulated Sprague Dawley rat at 10 mg/kg administered through oral gavage by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA3784918 | organism-based format | Scientific Literature | |
8. | ALA3789028 | B | Inhibition of human ERG by patch clamp method | Homo sapiens | 2 | ALA3784918 | assay format | Scientific Literature | |
9. | ALA3789029 | A | Inhibition of CYP1A2 (unknown origin) at 10 uM | Homo sapiens | 2 | ALA3784918 | single protein format | Scientific Literature | |
10. | ALA3789030 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM | Homo sapiens | 2 | ALA3784918 | single protein format | Scientific Literature | |
11. | ALA3789031 | A | Inhibition of CYP2D6 (unknown origin) at 10 uM | Homo sapiens | 2 | ALA3784918 | single protein format | Scientific Literature | |
12. | ALA3789032 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM | Homo sapiens | 2 | ALA3784918 | single protein format | Scientific Literature | |
13. | ALA3789033 | A | Inhibition of CYP2C19 (unknown origin) at 10 uM | Homo sapiens | 2 | ALA3784918 | single protein format | Scientific Literature | |
14. | ALA3789034 | A | Cmax in cannulated Sprague Dawley rat at 10 mg/kg administered through oral gavage by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA3784918 | organism-based format | Scientific Literature | |
15. | ALA3789035 | A | Half life in cannulated Sprague Dawley rat at 10 mg/kg administered through oral gavage by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA3784918 | organism-based format | Scientific Literature | |
16. | ALA3789036 | A | AUCt in cannulated Sprague Dawley rat at 10 mg/kg administered through oral gavage by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA3784918 | organism-based format | Scientific Literature | |
17. | ALA3789037 | A | AUCinfinity in cannulated Sprague Dawley rat at 10 mg/kg administered through oral gavage by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA3784918 | organism-based format | Scientific Literature | |
18. | ALA3789038 | F | Antitumor activity against human NCI-H3122 cells xenografted in SCID mouse assessed as tumor growth inhibition at 50 mg/kg, po administered qd for 14 days | Homo sapiens | 3 | ALA3784918 | organism-based format | Scientific Literature | |
19. | ALA3789303 | T | Toxicity in SCID mouse xenografted with human H3122 cells assessed as change in body weight at 50 mg/kg, po administered qd for 14 days measured during compound dosing | Mus musculus | 2 | ALA3784918 | organism-based format | Scientific Literature |