| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3791603 | B | Inhibition of wild type ALK (unknown origin) after 30 mins by HTRF assay | Homo sapiens | 21 | single protein format | Scientific Literature | ||
| 2. | ALA3791604 | B | Inhibition of ALK L1196M mutant (unknown origin) after 30 mins by HTRF assay | Homo sapiens | 21 | single protein format | Scientific Literature | ||
| 3. | ALA3791605 | B | Inhibition of EML4-ALK in human NCI-H3122 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 4. | ALA3791606 | B | Inhibition of ALK L1196M mutant in mouse BA/F3 cells assessed as inhibition of cell proliferation after 72 hrs by WST1 assay | Mus musculus | 21 | cell-based format | Scientific Literature | ||
| 5. | ALA3791607 | A | Metabolic stability of the compound in human liver microsomes assessed as compound remaining at 1 uM after 30 mins by LC/MS/MS analysis in the presence of NADPH | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 6. | ALA3791608 | A | Metabolic stability of the compound in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins by LC/MS/MS analysis in the presence of NADPH | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 7. | ALA3789027 | A | Tmax in cannulated Sprague Dawley rat at 10 mg/kg administered through oral gavage by LC/MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 8. | ALA3789028 | B | Inhibition of human ERG by patch clamp method | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 9. | ALA3789029 | A | Inhibition of CYP1A2 (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 10. | ALA3789030 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 11. | ALA3789031 | A | Inhibition of CYP2D6 (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA3789032 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA3789033 | A | Inhibition of CYP2C19 (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 14. | ALA3789034 | A | Cmax in cannulated Sprague Dawley rat at 10 mg/kg administered through oral gavage by LC/MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA3789035 | A | Half life in cannulated Sprague Dawley rat at 10 mg/kg administered through oral gavage by LC/MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA3789036 | A | AUCt in cannulated Sprague Dawley rat at 10 mg/kg administered through oral gavage by LC/MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 17. | ALA3789037 | A | AUCinfinity in cannulated Sprague Dawley rat at 10 mg/kg administered through oral gavage by LC/MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 18. | ALA3789038 | F | Antitumor activity against human NCI-H3122 cells xenografted in SCID mouse assessed as tumor growth inhibition at 50 mg/kg, po administered qd for 14 days | Homo sapiens | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA3789039 | F | Antitumor activity against human NCI-H3122 cells xenografted in SCID mouse assessed as tumor growth inhibition at 25 mg/kg, po administered qd for 14 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3789040 | B | Inhibition of human FAK at 1 uM after 30 mins by fluorescence assay in presence of ATP | Homo sapiens | 1 | single protein format | Scientific Literature |
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