# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3791346 | Functional | Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay | Homo sapiens | 19 | ALA3785041 | cell-based format | Scientific Literature | |
2. | ALA3791347 | Functional | Agonist activity at human FFA1 receptor expressed in human 1321N1 cells measured for 50 intervals of 0.4 secs by calcium mobilization assay relative to TUG-20 | Homo sapiens | 16 | ALA3785041 | cell-based format | Scientific Literature | |
3. | ALA3791348 | ADME | Drug metabolism in human liver microsomes assessed as cytochrome P450-mediated compound oxidation by measuring drug recovery after 1 hr by HPLC analysis | Homo sapiens | 3 | ALA3785041 | tissue-based format | Scientific Literature | |
4. | ALA3791349 | Physicochemical | Chemical stability in fasted state simulated gastric fluid assessed as drug recovery at 37 degC after 2 hrs | 1 | ALA3785041 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA3791350 | Binding | Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay | Homo sapiens | 18 | ALA3785041 | cell-based format | Scientific Literature | |
6. | ALA3791351 | Binding | Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay relative to TUG-424 | Homo sapiens | 11 | ALA3785041 | cell-based format | Scientific Literature | |
7. | ALA3791352 | Physicochemical | Lipophilicity, log D of compound at pH 7.4 | 1 | ALA3785041 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA3791353 | Physicochemical | Aqueous kinetic solubility in phosphate buffered saline at 200 uM by turbidimetric assay | 1 | ALA3785041 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA3791354 | Physicochemical | Chemical stability in 0.1 M phosphate buffered saline assessed as drug recovery at 37 degC after 24 hrs | 1 | ALA3785041 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA3791355 | Physicochemical | Chemical stability in fed state simulated intestinal fluid assessed as drug recovery at 37 degC after 2 hrs | 1 | ALA3785041 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA3791356 | Physicochemical | Chemical stability in fasted state simulated intestinal fluid assessed as drug recovery at 37 degC after 2 hrs | 1 | ALA3785041 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA3791357 | ADME | Cmax in C57BL/6 mouse plasma at 10 mg/kg, po | Mus musculus | 1 | ALA3785041 | organism-based format | Scientific Literature | |
13. | ALA3791358 | ADME | Tmax in C57BL/6 mouse plasma at 10 mg/kg, po | Mus musculus | 1 | ALA3785041 | organism-based format | Scientific Literature | |
14. | ALA3791359 | ADME | Half life in C57BL/6 mouse plasma at 10 mg/kg, po | Mus musculus | 1 | ALA3785041 | organism-based format | Scientific Literature | |
15. | ALA3791360 | ADME | AUC (0 to infinity) in C57BL/6 mouse plasma at 10 mg/kg, po | Mus musculus | 1 | ALA3785041 | organism-based format | Scientific Literature | |
16. | ALA3791361 | ADME | Clearance in C57BL/6 mouse plasma at 10 mg/kg, po | Mus musculus | 1 | ALA3785041 | organism-based format | Scientific Literature | |
17. | ALA3791609 | Functional | Antidiabetic activity in C57BL/6 mouse assessed as reduction in plasma glucose level at 10 mg/kg administered 15 mins through oral gavage prior to glucose challenge measured after 30 to 120 mins by OGTT | Mus musculus | 1 | ALA3785041 | organism-based format | Scientific Literature | |
18. | ALA3791610 | Functional | Antidiabetic activity in C57BL/6 mouse assessed as increase in plasma insulin level at 10 mg/kg administered 15 mins through oral gavage prior to glucose challenge measured after 30 mins by ELISA | Mus musculus | 1 | ALA3785041 | organism-based format | Scientific Literature | |
19. | ALA3791611 | Binding | Potency index, ratio of alpha-linolenic acid EC50 to compound EC50 for human FFA1 receptor expressed in human 1321N1 cells | Homo sapiens | 1 | ALA3785041 | cell-based format | Scientific Literature | |
20. | ALA3791612 | Unassigned | Ratio of Cmax in C57BL/6 mouse plasma to EC50 for human FFA1 receptor expressed in human 1321N1 cells | 1 | ALA3785041 | cell-based format | Scientific Literature |