| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3791613 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as decrease in LPS-induced p38 phosphorylation preincubated for 30 mins followed by LPS addition measured after 20 mins by Western blot analysis | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 2. | ALA3791614 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced TNF-alpha production at 10 uM incubated for 24 hrs by ELISA relative to control | Mus musculus | 4 | single protein format | Scientific Literature | ||
| 3. | ALA3791615 | F | Antiinflammatory activity in acute lung injury C57BL/6 mouse model assessed as inhibition of LPS-induced macrophage infilteration by measuring reduction in CD68 expression in lung tissues at 20 mg/kg, po treated 15 mins before LPS challenge measured after 6 hrs by DAB staining based immunohistochemical analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA3791616 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced TNF-alpha production incubated for 24 hrs by ELISA | Mus musculus | 4 | single protein format | Scientific Literature | ||
| 5. | ALA3791617 | A | Cytotoxicity against C57BL/6 mouse primary peritoneal macrophages assessed as reduction in cell viability at 10 uM after 24 hrs by MTT assay | Mus musculus | 34 | cell-based format | Scientific Literature | ||
| 6. | ALA3791618 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced IL-6 production incubated for 24 hrs by ELISA | Mus musculus | 4 | single protein format | Scientific Literature | ||
| 7. | ALA3791619 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as decrease in LPS-induced TNF-alpha mRNA expression at 10 uM preincubated for 30 mins followed by LPS addition measured after 6 hrs by qRT-PCR method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 8. | ALA3791620 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as decrease in LPS-induced IL-1beta mRNA expression at 10 uM preincubated for 30 mins followed by LPS addition measured after 6 hrs by qRT-PCR method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 9. | ALA3791621 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as decrease in LPS-induced IL-6 mRNA expression at 10 uM preincubated for 30 mins followed by LPS addition measured after 6 hrs by qRT-PCR method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 10. | ALA3791622 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as decrease in LPS-induced COX2 mRNA expression at 10 uM preincubated for 30 mins followed by LPS addition measured after 6 hrs by qRT-PCR method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 11. | ALA3791623 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as decrease in LPS-induced PGES mRNA expression at 10 uM preincubated for 30 mins followed by LPS addition measured after 6 hrs by qRT-PCR method | Mus musculus | 1 | assay format | Scientific Literature | ||
| 12. | ALA3791624 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as decrease in LPS-induced JNK phosphorylation preincubated for 30 mins followed by LPS addition measured after 20 mins by Western blot analysis | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 13. | ALA3791625 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as decrease in LPS-induced ERK phosphorylation preincubated for 30 mins followed by LPS addition measured after 20 mins by Western blot analysis | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 14. | ALA3791626 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced NF-kappaB p65 subunit nuclear translocation at 10 uM preincubated for 30 mins followed by LPS addition measured after 1 hr by DAPI staining based fluorescence microscopic analysis | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 15. | ALA3791627 | B | Inhibition of MD2/TLR4 complex formation in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kappaB transcriptional activity preincubated for 30 mins followed by LPS addition measured after 6 hrs by luciferase reporter gene assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3791628 | B | Inhibition of MD2/TLR4 complex formation in C57BL/6 mouse primary peritoneal macrophages assessed as reversal of LPS-induced IkB-alpha degradation preincubated for 30 mins followed by LPS addition measured after 1 hr by DAPI staining based fluorescence microscopic analysis | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 17. | ALA3791630 | B | Inhibition of recombinant human N-terminal GST-tagged JNK2 catalytic domain (1 to 364 residues) expressed in Escherichia coli using modified erktide as substrate at 0.05 to 50 uM after 1 hr by microfluidic assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA3791631 | B | Inhibition of full length recombinant human N-terminal GST-tagged ERK1 (1 to 379 residues) expressed in Escherichia coli using modified erktide as substrate at 0.05 to 50 uM after 1 hr by microfluidic assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA3791632 | B | Inhibition of recombinant human N-terminal GST-tagged p38-alpha (9 to 352 residues) expressed in Escherichia coli using modified erktide as substrate at 0.05 to 50 uM after 1 hr by microfluidic assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA3791883 | B | Inhibition of full length recombinant human N-terminal GST-tagged p38-beta (1 to 364 residues) expressed in Escherichia coli using modified erktide as substrate at 0.05 to 50 uM after 1 hr by microfluidic assay | Homo sapiens | 1 | assay format | Scientific Literature |
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