| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3791338 | F | Antiviral activity against HCV genotype 1a infected in human HuH7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR method | Hepacivirus hominis | 2 | ALA3785042 | organism-based format | Scientific Literature | |
| 2. | ALA3791339 | B | Inhibition of HCV genotype 1b full length NS3/4A protease using Ac-C(Eu)DDMEEAbu[COO]ASK(QSY7)-amide as substrate preincubated for 30 mins followed by substrate addition measured after 2.5 hrs by TRF assay | Hepatitis C virus subtype 1b | 5 | ALA3785042 | assay format | Scientific Literature | |
| 3. | ALA3791340 | B | Inhibition of HCV genotype 3a full length NS3/4A protease using Ac-C(Eu)DDMEEAbu[COO]ASK(QSY7)-amide as substrate preincubated for 30 mins followed by substrate addition measured after 2.5 hrs by TRF assay | Hepatitis C virus subtype 3a | 11 | ALA3785042 | assay format | Scientific Literature | |
| 4. | ALA3791341 | B | Inhibition of HCV genotype 1b NS3/4A protease R155K mutant using Ac-C(Eu)DDMEEAbu[COO]ASK(QSY7)-amide as substrate preincubated for 30 mins followed by substrate addition measured after 2.5 hrs by TRF assay | Hepatitis C virus subtype 1b | 5 | ALA3785042 | assay format | Scientific Literature | |
| 5. | ALA3788792 | B | Inhibition of HCV genotype 1b NS3/4A protease A156T mutant using Ac-C(Eu)DDMEEAbu[COO]ASK(QSY7)-amide as substrate preincubated for 30 mins followed by substrate addition measured after 2.5 hrs by TRF assay | Hepatitis C virus subtype 1b | 5 | ALA3785042 | assay format | Scientific Literature | |
| 6. | ALA3788793 | B | Inhibition of HCV genotype 1b NS3/4A protease A156V mutant using Ac-C(Eu)DDMEEAbu[COO]ASK(QSY7)-amide as substrate preincubated for 30 mins followed by substrate addition measured after 2.5 hrs by TRF assay | Hepatitis C virus subtype 1b | 5 | ALA3785042 | assay format | Scientific Literature | |
| 7. | ALA3788794 | B | Inhibition of HCV genotype 1b NS3/4A protease D168Y mutant using Ac-C(Eu)DDMEEAbu[COO]ASK(QSY7)-amide as substrate preincubated for 30 mins followed by substrate addition measured after 2.5 hrs by TRF assay | Hepatitis C virus subtype 1b | 5 | ALA3785042 | assay format | Scientific Literature | |
| 8. | ALA3788798 | A | AUC (0 to 24 hrs) in rat at 5 mg/kg, po | Rattus norvegicus | 8 | ALA3785042 | organism-based format | Scientific Literature | |
| 9. | ALA3788801 | B | Inhibition of HCV genotype 1a NS3/4A protease using Ac-C(Eu)DDMEEAbu[COO]ASK(QSY7)-amide as substrate preincubated for 30 mins followed by substrate addition measured after 2.5 hrs by TRF assay | Hepatitis C virus subtype 1a | 2 | ALA3785042 | assay format | Scientific Literature | |
| 10. | ALA3788803 | F | Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR method | Hepacivirus hominis | 2 | ALA3785042 | organism-based format | Scientific Literature | |
| 11. | ALA3788804 | F | Antiviral activity against HCV genotype 2a infected in human HuH7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR method | Hepacivirus hominis | 2 | ALA3785042 | organism-based format | Scientific Literature | |
| 12. | ALA3788805 | F | Antiviral activity against HCV genotype 2b infected in human HuH7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR method | Hepacivirus hominis | 2 | ALA3785042 | organism-based format | Scientific Literature | |
| 13. | ALA3788806 | F | Antiviral activity against HCV genotype 3a infected in human HuH7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR method | Hepacivirus hominis | 2 | ALA3785042 | organism-based format | Scientific Literature | |
| 14. | ALA3788807 | F | Antiviral activity against HCV genotype 1a infected in human HuH7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR method in presence of 100% normal human serum | Hepacivirus hominis | 1 | ALA3785042 | organism-based format | Scientific Literature | |
| 15. | ALA3788808 | F | Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR method in presence of 100% normal human serum | Hepacivirus hominis | 1 | ALA3785042 | organism-based format | Scientific Literature | |
| 16. | ALA3788809 | F | Antiviral activity against HCV genotype 2a infected in human HuH7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR method in presence of 100% normal human serum | Hepacivirus hominis | 1 | ALA3785042 | organism-based format | Scientific Literature | |
| 17. | ALA3788810 | F | Antiviral activity against HCV genotype 3a infected in human HuH7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR method in presence of 100% normal human serum | Hepacivirus hominis | 1 | ALA3785042 | organism-based format | Scientific Literature | |
| 18. | ALA3788812 | A | Oral bioavailability in rat at 5 mg/kg | Rattus norvegicus | 2 | ALA3785042 | organism-based format | Scientific Literature | |
| 19. | ALA3788813 | A | Inhibition of CYP3A4 (unknown origin) up to 50 uM | Homo sapiens | 1 | ALA3785042 | single protein format | Scientific Literature | |
| 20. | ALA3788814 | A | Inhibition of CYP2C9 (unknown origin) up to 50 uM | Homo sapiens | 1 | ALA3785042 | single protein format | Scientific Literature |
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